Peroxisomal remnants in peroxisome-deficient mutants of the yeast Hansenula polymorpha [corrected

FEBS Letters
M VeenhuisIda J van der Klei

Abstract

We have analyzed the presence of peroxisomal remnants ('ghosts') in three peroxisome-deficient (per) mutants of the yeast Hansenula polymorpha, namely delta per4, delta per5 and delta per10. Under peroxisome-inducing growth conditions peroxisomal membrane proteins (PMPs) were normally synthesized in cells of these mutants. In addition, these cells contained clusters of small membraneous vesicles, which were absent in cells grown under peroxisome-repressing growth conditions. These structures displayed typical peroxisomal properties in that they proliferated upon overproduction of Per8p, the H. polymorpha peroxisome proliferation factor. Moreover, in delta per4 and delta per5 these vesicles were susceptible to glucose-induced proteolytic degradation.

References

Jan 1, 1992·Annual Review of Biochemistry·H van den BoschJ M Tager
Sep 1, 1992·Cell Biochemistry and Function·M Veenhuis
Aug 1, 1992·Journal of Bacteriology·H LiuJ M Cregg
Jan 1, 1993·Annual Review of Cell Biology·S Subramani
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·V I TitorenkoM Veenhuis

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Citations

Feb 3, 1998·Trends in Microbiology·I J van der Klei, M Veenhuis
Mar 6, 1999·Current Opinion in Microbiology·W H Kunau
Aug 31, 2000·Annual Review of Biochemistry·J Kim, D J Klionsky
Sep 8, 2004·Trends in Cell Biology·Jean-Claude Farré, Suresh Subramani
Nov 14, 2003·FEMS Yeast Research·Adriana N Leão, Jan A K W Kiel
Sep 11, 2002·The Journal of Biological Chemistry·Anna Rita BelluIda J Van Der Klei
Sep 5, 2001·The Journal of Biological Chemistry·P E StrømhaugW A Dunn
Jan 16, 2002·The Journal of Biological Chemistry·Klaas Nico FaberMarten Veenhuis
May 13, 2003·Microscopy Research and Technique·Anna Rita Bellu, Jan A K W Kiel
Feb 13, 2001·Microscopy Research and Technique·M VeenhuisI J Van Der Klei
Sep 22, 2018·Histochemistry and Cell Biology·Tanja Eberhart, Werner J Kovacs
Sep 21, 2001·The Journal of Biological Chemistry·A R BelluM Veenhuis

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