Dec 1, 1975

Peroxisome development in the metanephric kidney of mouse

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
J A Goeckermann, E L Vigil


The relationship of enzymatic activity to organelle development and organelle number during differentiation of the metanephric kidney in the mouse was approached from several experimental directions. Biochemical analyses of marker enzymes for peroxisomes (catalase and D-amino acid oxidase), mitochondria (cytochrome oxidase) and lysosomes (acid phosphatase) were performed on kidneys at ages from 17 days prenatal to adult. These data were correlated with a morphometric analysis of populations of peroxisomes and mitochondria in differentiating cells of the proximal tubule. Postnatal development of the metanephric kidney was found to be accompanied by a rapid increase in both the specific activity of catalase and the number of peroxisomes per 100 mu2 in the proximal tubule during the first 4 weeks of postnatal growth. Elaboration of the endoplasmic reticulum (ER) was seen to parallel the increase in number of peroxisomes to which segments of ER were often in close apposition. Extensive interactions between segments of ER and peroxisomes were readily visible in 0.5-mu sections viewed in the high voltage electron microscope. In contrast to peroxisomes, neither mitochondria nor lysosomes followed a similar pattern of net organelle inc...Continue Reading

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Mentioned in this Paper

Acid Phosphatase
Cytochrome C Oxidase
D-Amino Acid Dehydrogenase
Cytochrome c Oxidase Subunit VIa
Fetal Structures
Enzymes, antithrombotic
DAO gene

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