Peroxisome proliferator-activated receptor-α staining is associated with worse outcome in colorectal liver metastases

Molecular and Clinical Oncology
Tony PangJaswinder Samra

Abstract

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors involved in lipid metabolism and liver response to injury. We hypothesised that differences in the expression of PPARs may reflect differences in the cellular microenvironment of the liver and, consequently, in the behaviour of colorectal liver metastases. Of the 145 patients who underwent hepatectomy for colorectal liver metastases between 1998 and 2007, 103 had adequate tissue for PPAR staining and histological re-evaluation. The histological characteristics evaluated included sinusoidal dilatation, perisinusoidal fibrosis, ballooning and steatosis. PPAR- α and-γ staining was performed and the results were correlated with clinical and survival data. Lobular inflammation and sinusoidal dilatation were the most common histopathological abnormalities. A total of 50% of the patients were PPAR- α-negative and 34% were PPAR- γ-negative. More patients exhibited lobular inflammation in the PPAR- α -positive group (P=0.023) compared to patients with negative PPAR- α staining, as seen on the multivariate analysis. PPAR- γpositivity was associated with oxaliplatin use, surgical margins ≥1 mm and a trend towards a lesser degree of fibrosis. The median f...Continue Reading

References

Apr 18, 2001·The Oncologist·P D King, M C Perry
Nov 15, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tomohisa Okaya, Alex B Lentsch
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Rubbia-BrandtB Terris
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyEddie K Abdalla
Jun 17, 2006·Current Opinion in Pharmacology·Giovanni Rizzo, Stefano Fiorucci
Jul 22, 2006·Annals of Surgery·Sylvain ManfrediAnne-Marie Bouvier
Mar 1, 2007·PloS One·Arja KaipainenDipak Panigrahy
Mar 31, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Rosanna Di Paola, Salvatore Cuzzocrea
Dec 28, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N N MehtaD F Mirza
Feb 15, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S KandutschT Gruenberger
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 16, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jose M RamiaJoan Figueras
Jul 9, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Deepa NaishadhamAhmedin Jemal
Feb 10, 2012·Nature Reviews. Cancer·Jeffrey M PetersFrank J Gonzalez

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Citations

Dec 26, 2017·ChemMedChem·Laura De LellisAlessandra Ammazzalorso
Aug 20, 2020·Acta Cirúrgica Brasileira·Andre Luiz Prezotto VillaOmar Feres
Jan 24, 2016·Journal of Translational Medicine·Javier Martinez-Useros, Jesus Garcia-Foncillas

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