PMID: 16503871Mar 1, 2006Paper

Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis

Current Drug Targets. Cardiovascular & Haematological Disorders
I Gouni-Berthold, W Krone

Abstract

The peroxisome proliferator-activated receptors (PPARs) alpha, beta/delta and gamma are ligand-activated transcription factors belonging to the nuclear receptor superfamily. PPARs heterodimerize with the retinoid X receptor (RXR) and modulate the function of many target genes. They were originally described as regulators of various metabolic, pathways, but have been recently found to also exert modulating actions in the vascular wall. PPARalpha is activated by endogenous ligands, such as polyunsaturated fatty acids and by synthetic agonists such as the fibrates. PPARalpha is expressed mainly in the liver, kidney and skeletal muscle and is involved in fatty acid oxidation. However, it is also expressed in vascular cells such as the endothelial cells, vascular smooth muscle cells and macrophages, where it exerts anti-inflammatory and antioxidant effects. Since atherosclerosis is both a chronic inflammatory and a lipid disorder and since PPARalpha is expressed in vascular cells and regulates the expression of genes involved in lipid metabolism and inflammation, PPARalpha activators may constitute useful agents for the prevention of atherosclerosis, beyond their effects on lipid metabolism. This review will focus on the functions o...Continue Reading

Citations

Jul 24, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xingguo Cheng, Curtis D Klaassen
Aug 16, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xingguo Cheng, Curtis D Klaassen
Jun 11, 2009·Current Opinion in Lipidology·Fredrik Karpe, Ewa E Ehrenborg
Jul 12, 2011·Expert Opinion on Therapeutic Targets·Emanuela Esposito, Salvatore Cuzzocrea
Nov 16, 2007·Medicinal Research Reviews·R L TiwariM K Barthwal
Dec 2, 2010·Journal of Clinical Pharmacology·Robert Krysiak, Boguslaw Okopien
Sep 27, 2012·Journal of the Science of Food and Agriculture·Qin LiJiehui Hu
Oct 7, 2015·Journal of Diabetes and Its Complications·Kalliopi PafiliDimitri P Mikhailidis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.