Peroxisome proliferator-activated receptor alpha accelerates neuronal differentiation and this might involve the mitogen-activated protein kinase pathway

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Chingju LinNai Wen Chang

Abstract

Activation of peroxisome proliferator-activated receptor alpha (PPARα) has been reported to modulate cell proliferation, migration, and differentiation in astrocytes. In this study, we used a retinoic acid (RA)-induced differentiation model of NTERA-2/clone D1 (NT2) cells to explore the functional significance of PPARα in neuronal differentiation. We found that activating PPARα by Wy14643 accelerated neuronal differentiation via regulating the expression of neuronal markers. RT-PCR assays showed a significant increase in NeuroD expression and a decrease in nestin expression in cells treated concomitantly with RA and Wy14643 for 2 days compared to the levels in cells treated with RA alone. Expression of MAP2 protein, a mature neuronal marker, was markedly upregulated at day 10 of Wy14643 treatment, which was maintained after 21 days of neuronal formation. Corresponding to the changes in MAP2 expression, the expression of Cdk5 was upregulated with Wy14643 exposure from day 10 to day 21. Moreover, cells treated with Wy14643 displayed higher expression levels of phospho-ERK and phospho-p38 in the differentiation process than cell treated with RA alone. These results indicated that activation of PPARα accelerated neuronal differenti...Continue Reading

References

Jan 1, 1996·Annual Review of Neuroscience·R A Segal, M E Greenberg
Jan 1, 1996·International Review of Cytology·S R Heidemann
Jan 17, 1997·The Journal of Biological Chemistry·P DowellM Leid
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
Nov 18, 2000·Journal of Neuropathology and Experimental Neurology·X ZhuM A Smith
Oct 26, 2002·Science·Dennis J Selkoe
Oct 31, 2003·The Journal of Biological Chemistry·Faith M HarrisYadong Huang
Nov 30, 2004·Neuroscience Letters·Francesca MegiorniMaria Cristina Mazzilli
Oct 6, 2005·The Journal of Biological Chemistry·Manuel J SantosNibaldo C Inestrosa
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony A OlivaGary A Banker
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Christian Haass, Dennis J Selkoe
Mar 21, 2007·Vitamins and Hormones·Dianne Robert SopranoKenneth J Soprano
Mar 29, 2007·Journal of Cellular Physiology·S Di LoretoA Cimini
Sep 21, 2007·Nature Reviews. Neuroscience·Malcolm Maden
Feb 12, 2008·Current Biology : CB·Federico Dajas-BailadorAlan J Whitmarsh
Mar 14, 2008·Current Medicinal Chemistry·M MilosoG Tredici
Jul 25, 2008·Nature·Steven J Bensinger, Peter Tontonoz
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Koji OishiYukiko Gotoh
Apr 27, 2011·Journal of Cellular Physiology·B D'AngeloA Cimini
Feb 14, 2012·Biochemical and Biophysical Research Communications·Yoon Ki HongKyoung Sang Cho
Mar 15, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giuseppe D'AgostinoAntonio Calignano
Dec 5, 2012·International Review of Neurobiology·Tao YeNancy Y Ip
Jan 9, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thavarak OukRégis Bordet
Aug 1, 2015·Molecular Neurobiology·Shu-Lei LiuJin-Tai Yu
Nov 5, 2016·The American Journal of Chinese Medicine·Quan Feng LiuKyoung Sang Cho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
Jung-Sook YoonJeong-Hwa Lee
© 2022 Meta ULC. All rights reserved