Peroxisome Proliferator-Activated Receptor γ and Its Role in Adipocyte Homeostasis and Thiazolidinedione-Mediated Insulin Sensitization

Molecular and Cellular Biology
Qiong A WangPhilipp E Scherer

Abstract

Adipose tissue is a dynamic organ that makes critical contributions to whole-body metabolic homeostasis. Although recent studies have revealed that different fat depots have distinct molecular signatures, metabolic functions and adipogenic mechanisms, peroxisome proliferator-activated receptor γ (PPARγ) is still widely viewed as the master regulator of adipogenesis and critical for maintaining mature adipocyte function. Using an inducible, adipocyte-specific knockout system, we explored the role of PPARγ in mature adipocytes in vivo Short-term PPARγ deficiency in adipocytes reduces whole-body insulin sensitivity, but adipocytes are viable both in vitro and in vivo However, after exposure to a high-fat diet, even short-term PPARγ deficiency leads to rapid adipocyte death. When mature adipocytes are depleted of both PPARγ and CCAAT-enhancer-binding protein α (C/EBPα), they are rapidly depleted of lipids and undergo adipocyte death, both in vitro and in vivo Surprisingly, although thiazolidinediones (TZDs; PPARγ agonists) are thought to act mainly on PPARγ, PPARγ in adipocytes is not required for the whole-body insulin-sensitizing effect of TZDs. This offers new mechanistic aspects of PPARγ/TZD action and its effect on whole-body ...Continue Reading

References

Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
Jan 1, 1995·Molecular and Cellular Biology·P TontonozB M Spiegelman
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Chawla, M A Lazar
Jul 30, 2002·Proceedings of the National Academy of Sciences of the United States of America·Anne-Karina T PerlJeffrey A Whitsett
Oct 23, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jerry R ColcaW Rodney Mathews
Nov 20, 2003·Nature Medicine·Andrea L HevenerJerrold Olefsky
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Weimin HeRonald M Evans
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takeshi ImaiDaniel Metzger
Apr 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Julie R JonesMark A Magnuson
Jun 7, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D MetzgerP Chambon
Dec 7, 2007·Nature Medicine·Yihong WanRonald M Evans
Nov 5, 2008·Genes & Development·Martina I LefterovaMitchell A Lazar
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qiong WangYong Liu
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Shigeki SugiiRonald M Evans
Dec 16, 2011·American Journal of Physiology. Renal Physiology·Emily BorstingRobyn Cunard
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kai SunPhilipp E Scherer
Mar 7, 2013·Clinical Pharmacology and Therapeutics·J R ColcaD G Orloff
Sep 21, 2013·Molecular Metabolism·Risheng Ye, Philipp E Scherer
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Fenfen WangMitchell A Lazar
Jan 21, 2014·Cell·Evan D Rosen, Bruce M Spiegelman
Aug 19, 2015·Nature Cell Biology·Qiong A WangPhilipp E Scherer
Jun 4, 2016·Nature Reviews. Drug Discovery·Christine M KusminskiPhilipp E Scherer

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Citations

May 28, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Fatemeh KhatamiSeyed M Tavangar
Aug 23, 2020·Scientific Reports·Brooks TaylorEwa Bielczyk-Maczyńska
Sep 7, 2018·Frontiers in Endocrinology·Xinran MaLingyan Xu
Jul 12, 2020·Journal of Clinical Medicine·Lucy V TrevorM Julie Thornton
Nov 6, 2020·Experimental Eye Research·Miaozhen PanXiangtian Zhou
May 7, 2021·Frontiers in Endocrinology·Abhijit Babaji ShindeQiong A Wang
Jun 27, 2021·Scientific Reports·Irini GergesAlessandro Tocchio

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