Peroxisome proliferator-activated receptor gamma (PPARgamma) activation and its consequences in humans

Toxicology Letters
J Bar-Tana

Abstract

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the superfamily of nuclear receptors. It binds and is activated by natural polyunsaturated fatty acids, eicosanoids, synthetic thiazolidinediones and related analogues. Biological effects exerted by PPARgamma ligands are mostly concerned with differentiation processes, sensitization to insulin and atherogenesis, and are paradigmatically ascribed to PPARgamma transactivation of PPARgamma-responsive genes. The PPARgamma paradigm and its consequences in humans are analyzed here in terms of the tissue specificity of PPARgamma, loss and gain of function mutants of PPARgamma, PPARgamma-responsive genes and clinical effects of PPARgamma ligands. Differentiation, as well as some of the atherogenic effects induced by PPARgamma ligands, does conform to the PPARgamma paradigm. However, sensitization to insulin as well as some of the antiatherogenic effects of PPARgamma ligands is not accounted for by PPARgamma activation, thus calling for an alternative target for insulin sensitizers.

References

Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·E HuB M Spiegelman
May 15, 1994·Genes & Development·P TontonozB M Spiegelman
Oct 15, 1996·The Journal of Clinical Investigation·R E LawW A Hsueh
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·P TontonozB M Spiegelman
Oct 6, 1997·The Journal of Clinical Investigation·M ShimabukuroR H Unger
Feb 12, 1998·The Journal of Clinical Investigation·C F BurantR A Graves
May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·Y NakashimaR Ross
Jul 14, 1998·Molecular Cell·E MuellerB M Spiegelman
Oct 1, 1998·The New England Journal of Medicine·M RistowC R Kahn
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·G D DemetriS Singer
Feb 17, 2000·The Journal of Clinical Investigation·P D MilesJ M Olefsky
Aug 11, 2000·Diabetes Care·S AkazawaK Eguchi
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·E MuellerP W Kantoff
Sep 23, 2000·Nature·A J Lusis

❮ Previous
Next ❯

Citations

Sep 6, 2003·International Journal of Cardiology·Paolo PudduAntonio Muscari
May 16, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stamatios TheocharisAntonios Koutselinis
Mar 29, 2002·Kidney International·Robert Earl RouthKevin John McCarthy
Apr 23, 2014·Biochemical and Biophysical Research Communications·Ranzun ZhaoGuoxiang He
Mar 15, 2006·Archives of Biochemistry and Biophysics·M Clara De PascaleJean-Marc Zingg
Jun 30, 2005·International Journal of Cancer. Journal International Du Cancer·AnnaMaria CiminiMaria Paola Cerù
Dec 3, 2014·European Journal of Medicinal Chemistry·Vivek AsatiSanjay K Bharti
Aug 25, 2004·Cancer Treatment Reviews·Stamos TheocharisGregory Kouraklis
Sep 5, 2002·Medicinal Research Reviews·Roman A Blaheta, Jindrich Cinatl
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Jinah HwangC Michael Hart
May 11, 2002·The Proceedings of the Nutrition Society·Miriam N Jacobs, David F V Lewis
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara FischerBernhard Brüne
Jul 2, 2005·Biochemical and Biophysical Research Communications·H B LiuA E Dear

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.