Peroxisome proliferator activated receptor gamma agonists suppress TNFalpha-induced ICAM-1 expression by endothelial cells in a manner potentially dependent on inhibition of reactive oxygen species

Immunology Letters
Yuyeon JungChulhee Choi

Abstract

In this study, we investigated the anti-inflammatory effect of various peroxisome proliferator activated receptor gamma (PPARgamma) agonists (15-deoxy-Delta12,14-prostaglandin J(2), troglitazone, rosiglitazone, ciglitazone) on human aortic endothelial cells. Pretreatment with PPARgamma agonists abrogated tumor necrosis factor alpha (TNFalpha)-induced expression of intercellular adhesion molecule-1 (ICAM-1) and subsequent monocytic adhesion by endothelial cells. Because reactive oxygen species (ROS) have been reported to play important roles in pro-inflammatory signal transduction, the involvement of ROS was investigated as a potential mechanism of anti-inflammatory effect of PPARgamma ligands. Consistent with previous reports in other cell types, blockade of TNFalpha-induced ROS by treatment with N-acetylcysteine, diphenylene iodonium or NADPH oxidase 4 (NOX4) siRNA suppressed TNFalpha-induced ICAM-1 expression and subsequent monocytic adhesion, indicating that TNFalpha mediates pro-inflammatory signals via NOX4-dependent ROS generation in human endothelial cells. Finally, pretreatment with PPARgamma agonists significantly suppressed TNFalpha-induced increases of intracellular ROS. Our results collectively suggest that PPARgamm...Continue Reading

References

Jun 9, 1997·Biochemical and Biophysical Research Communications·I InoueT Komoda
Apr 30, 1999·Science·S A KliewerT M Willson
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D S StrausC K Glass
May 29, 2000·The Journal of Biological Chemistry·H InoueK Umesono
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Nov 29, 2002·Nature Medicine·John M Hallenbeck
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Xi-Lin ChenRussell M Medford
Oct 22, 2003·Circulation·Paul E SzmitkoSubodh Verma
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mahboob H QureshiBeth A Garvy
Oct 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xi-Lin ChenRussell M Medford
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Jean-Claude TardifPhilippe L L'Allier
Sep 24, 2005·Nature Immunology·Shannon T Bailey, Sankar Ghosh

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Citations

Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing XiaoKar Neng Lai
May 11, 2012·American Journal of Physiology. Cell Physiology·Clintoria R WilliamsC Michael Hart
Dec 3, 2011·PPAR Research·Jia FeiNalini Santanam
Oct 12, 2011·Expert Review of Cardiovascular Therapy·Caroline Jane MagriStephen Fava
Feb 23, 2011·Cell Adhesion & Migration·Zacharoula ZolotaMartha Kaloyianni
Jan 1, 2008·PPAR Research·Peter E Westerweel, Marianne C Verhaar
Aug 25, 2016·BioMed Research International·Fu-Chao LiuHuang-Ping Yu
Feb 7, 2020·Journal of Cosmetic Dermatology·Hecong WangCongfen He
May 20, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kate A ParhamClaudine S Bonder
May 28, 2009·Macromolecular Bioscience·Pierre-Luc Girard-LauriaultMichael R Wertheimer
Jun 29, 2018·International Journal of Molecular Sciences·Michele D'AngeloElisabetta Benedetti
Oct 30, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aravind T ReddyRaju C Reddy
Jun 3, 2021·International Journal of Molecular Sciences·Chun LiHong Sun
Jul 28, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ylva EdlingMonica Ek

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