Peroxisome proliferator-activated receptor-gamma agonists suppress iNOS expression induced by LPS in rat primary Schwann cells

Journal of Neuroimmunology
Fupeng ZhangChun Cheng

Abstract

In bacterial-induced peripheral nervous system (PNS) inflammation, Schwann cells (SCs) are activated, producing inducible nitric oxide synthase (iNOS), contributed to the pathogenesis of demyelinating disease, such as multiple sclerosis. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been shown to play a protective role in cellular inflammatory responses. Here we showed that LPS-induced iNOS biosynthesis was in a concentration and time-dependent manner. In LPS-treated primary SCs, retreatment with PPAR-gamma agonist remitted the increase of iNOS, p38 phosphorylation and TLR4, MyD88, augmented the expression of PPAR-gamma and localization in nuclear. Coadministration of GW 9662 reversed the effect of PPAR-gamma agonists. These results suggest that PPAR-gamma agonists, 15d-PGJ(2) and pioglitazone, had the anti-inflammatory effects.

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Citations

Apr 7, 2012·PPAR Research·Simone PolvaniAndrea Galli
Aug 1, 2015·Cytotechnology·Reyhaneh DarehgazaniMohammad Hossein Nasr-Esfahani
Nov 18, 2017·PLoS Neglected Tropical Diseases·Caroline IsaacLaure Guenin-Macé
May 18, 2017·The Clinical Journal of Pain·Danielle N LyonsKarin N Westlund
Jul 13, 2021·Journal of Medicinal Chemistry·Sabine WillemsDaniel Merk

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