Peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha gene polymorphisms in Korean women with polycystic ovary syndrome

Gynecologic and Obstetric Investigation
Soo Jin ChaeShin Yong Moon

Abstract

To investigate whether the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) Pro12Ala and the PPAR-gamma coactivator-1alpha (PGC-1alpha) Gly482Ser polymorphisms were associated with polycystic ovary syndrome (PCOS). Genetic analyses of the PPAR-gamma Pro12Ala and the PGC-1alpha Gly482Ser polymorphisms were performed in 184 patients with PCOS and 256 controls. Hormone levels, biochemical and clinical features were analyzed according to these polymorphisms. Neither the PPAR-gammaPro12Ala nor the PGC-1alpha Gly482Ser polymorphism showed significant differences in genotypic distribution between women with PCOS and controls. In PCOS patients, women with the non-Pro/Pro genotypes of the PPAR-gamma Pro12Ala polymorphism showed statistically significantly higher HDL levels than those with the Pro/Pro genotype (p = 0.002). PCOS patients who had the Ser/Ser genotype of the PGC-1alpha Gly482Ser polymorphism had significantly higher levels of postprandial 2-hour insulin than those with the Gly/Ser genotype (p = 0.045). Neither the PPAR-gammaPro12Ala nor the PGC-1alpha Gly482Ser polymorphism were supposed to be susceptible genes in PCOS. However, in PCOS patients, the PPAR-gammaPro12Ala and the PGC-1alpha Gly482Ser polymorphism ...Continue Reading

Citations

Apr 25, 2012·Journal of Assisted Reproduction and Genetics·Junli HeXuliang Li
Jun 25, 2013·Journal of Assisted Reproduction and Genetics·Bhaskar Venkata Kameswara Subrahmanya LakkakulaUsha Rani Godla
Oct 5, 2010·PPAR Research·Yuji NaitoToshikazu Yoshikawa
Dec 12, 2017·Systems Biology in Reproductive Medicine·Ritu DeswalAmita Suneja Dang
Oct 31, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Youn Kyung ChungYoung Min Choi

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