Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates promyogenic signaling pathways, thereby promoting myoblast differentiation

Biochemical and Biophysical Research Communications
Sang-Jin LeeGyu-Un Bae

Abstract

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) regulates postnatal myogenesis by alleviating myostatin activity, but the molecular mechanisms by which it regulates myogenesis are not fully understood. In this study, we investigate molecular mechanisms of PPARβ/δ in myoblast differentiation. C2C12 myoblasts treated with a PPARβ/δ agonist, GW0742 exhibit enhanced myotube formation and muscle-specific gene expression. GW0742 treatment dramatically activates promyogenic kinases, p38MAPK and Akt, in a dose-dependent manner. GW0742-stimulated myoblast differentiation is mediated by p38MAPK and Akt, since it failed to restore myoblast differentiation repressed by inhibition of p38MAPK and Akt. In addition, GW0742 treatment enhances MyoD-reporter activities. Consistently, overexpression of PPARβ/δ enhances myoblast differentiation accompanied by elevated activation of p38MAPK and Akt. Collectively, these results suggest that PPARβ/δ enhances myoblast differentiation through activation of promyogenic signaling pathways.

References

Jul 27, 2002·Annual Review of Cell and Developmental Biology·Mary Elizabeth PownallCharles P Emerson
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jong-Sun KangRobert S Krauss
Jun 23, 2004·Nature Genetics·Cristiano SimonePier Lorenzo Puri
Jun 1, 2005·Journal of Cell Science·Robert S KraussJong-Sun Kang
Nov 30, 2006·Pharmacological Reviews·Liliane MichalikWalter Wahli
May 21, 2010·Molecular Biology of the Cell·Gyu-Un BaeJong-Sun Kang
Dec 3, 2014·Biochemical and Biophysical Research Communications·Sang-Jin LeeGyu-Un Bae
Jul 8, 2015·Biochemical and Biophysical Research Communications·A RetamalesJ A Valdés

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Citations

Jul 13, 2018·International Journal of Molecular Sciences·Ajit Magadum, Felix B Engel
Jan 1, 2018·Nuclear Receptor Research·Qinglin Yang, Qinqiang Long

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