PMID: 16515475Mar 7, 2006Paper

Peroxisome proliferator-activated receptors and the control of fatty acid oxidation in cardiac hypertrophy

Mini Reviews in Medicinal Chemistry
Anna PlanavilaManuel Vázquez-Carrera

Abstract

Cardiac hypertrophy is a response of the heart to a wide range of extrinsic stimuli, such as arterial hypertension, valvular heart disease, myocardial infarction, and cardiomyopathy. Although this process is initially compensatory for an increase workload, its prolongation frequently results in congestive heart failure, arrhythmia, and sudden death. Cardiac hypertrophy is associated with an increase in glucose utilization and a decrease in fatty acid oxidation. It is unclear at present, however, which consequences might result from impaired oxidation of fatty acids in the heart, but several studies have demonstrated that substrate utilization is important in the pathogenesis of cardiac hypertrophy. Here we will focus on the effects of cardiac hypertrophy on the activity of Peroxisome proliferator-activated receptors (PPARs), ligand-activated transcription factors that regulate the expression of genes involved in fatty acid uptake and oxidation, lipid metabolism and inflammation. Interestingly, activation of the Nuclear Factor (NF)-kappaB signaling pathway, which is one of the most important signal transduction pathways involved in the hypertrophic growth of the myocardium, may suppress the activity of the PPARs, affording a lin...Continue Reading

Citations

Mar 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Yuan-Wen ChenLouis J Dell'italia
Sep 12, 2015·The Journal of Nutritional Biochemistry·Joan VillarroyaAnna Planavila
Sep 19, 2007·Aging Cell·Nancy J LinfordPeter S Rabinovitch
Oct 18, 2015·International Journal of Cardiology·I Redondo-AnguloA Planavila
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yanqing ZhangLong Chen
May 5, 2017·Cardiovascular Research·Ibon Redondo-AnguloAnna Planavila

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