Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Folia Histochemica Et Cytobiologica
I BogackaKatarzyna Chojnowska

Abstract

Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has al...Continue Reading

Citations

May 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·James A HorscroftAndrew J Murray
May 2, 2019·Reproduction, Fertility, and Development·Silvana R FerreiraAlicia B Motta
Sep 27, 2019·Frontiers in Physiology·Sushil Bhandari, Gianpiero L Cavalleri
Sep 19, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Chun-Yi GuanHong-Fei Xia
Jan 8, 2021·International Journal of Molecular Sciences·Lin PengViktoria von Schönfeldt
Jul 6, 2021·Frontiers in Endocrinology·Melissa L KozakiewiczAllyn C Howlett

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