Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases

Frontiers in Pharmacology
Juan DecaraJuan Suárez

Abstract

The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that promote ligand-dependent transcription of target genes that regulate energy production, lipid metabolism, and inflammation. The PPAR superfamily comprises three subtypes, PPARα, PPARγ, and PPARβ/δ, with differential tissue distributions. In addition to their different roles in the regulation of energy balance and carbohydrate and lipid metabolism, an emerging function of PPARs includes normal homeostasis of intestinal tissue. PPARα activation represses NF-κB signaling, which decreases the inflammatory cytokine production by different cell types, while PPARγ ligands can inhibit activation of macrophages and the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and Il-1β. In this regard, the anti-inflammatory responses induced by PPAR activation might restore physiopathological imbalances associated with inflammatory bowel diseases (IBD). Thus, PPARs and their ligands have important therapeutic potential. This review briefly discusses the roles of PPARs in the physiopathology and therapies of the most important IBDs, ulcerative colitis (UC), and Crohn's disease (CD), as well so...Continue Reading

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Citations

Jan 28, 2021·International Journal of Molecular Sciences·Ana Lago-FernandezPaula Morales
Feb 27, 2021·Frontiers in Immunology·Wonki KimYoung-Joon Surh
Jun 5, 2021·Free Radical Biology & Medicine·Ji Tae KimB Mark Evers
Aug 22, 2021·Journal of Equine Veterinary Science·Giorgia GaliazzoRoberto Chiocchetti
Sep 17, 2021·Journal of Crohn's & Colitis·Roger SuauJosep Manyé

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Methods Mentioned

BETA
nuclear translocation
pharmacotherapies

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