Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats

Toxicology Letters
Wan-Seob ChoDong Deuk Jang

Abstract

Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-alpha activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.

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Citations

Nov 21, 2012·Environmental Health Perspectives·Randi J BertelsenMartinus Løvik
Oct 12, 2010·Pharmaceutical Statistics·Ludwig A Hothorn, Gemechis D Djira
Sep 1, 2011·Toxicological Research·Bang Hyun KimBeom Seok Han
Mar 27, 2009·Journal of Basic Microbiology·Jae-Min ParkYang-Hoon Kim
May 21, 2015·The Journal of Clinical Endocrinology and Metabolism·Teresa M Attina, Leonardo Trasande

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