Peroxisome proliferators alter lipid acquisition and elastin gene expression in neonatal rat lung fibroblasts

The American Journal of Physiology
S E McGowanP J Olson

Abstract

During the alveolar stage of lung development, lipid droplet-laden interstitial cells are present at the base of elongating alveolar septa. These cells that have been named lipid interstitial cells or lipofibroblasts (LFs) may supply lipids for surfactant production, the synthesis of membrane phospholipids, and/or energy metabolism. They also have myofibroblastic characteristics and participate in the generation of the interstitial elastic fiber network, that is, in the pulmonary alveolar septum. To understand how this cell regulates its lipid-storing and elastin-producing properties, we have examined the effects of peroxisome proliferators on the expression of the genes that are associated with an elastin-producing myofibroblastic phenotype or an adipocyte-like phenotype. Two known ligands for peroxisome proliferator-activated receptors, 5,8,11,14-eicosatetraynoic acid (ETYA) and 15-deoxy-delta-12,14-prostaglandin J2 (15-dPGJ2), decrease elastin gene transcription and the steady-state levels of tropoelastin (TE) and alpha-smooth muscle actin mRNAs in cultured LFs. Concurrently, cultured LFs increase the expression of adipocyte lipid binding protein, which is regarded as an adipocyte-specific protein, and accumulate lipid dropl...Continue Reading

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Citations

Mar 7, 2002·American Journal of Physiology. Renal Physiology·Feng ZhengGary E Striker
Aug 26, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowan, Diann M McCoy
Sep 7, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Katrin Ahlbrecht, Stephen E McGowan
Mar 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen E McGowan
Feb 25, 2021·Stem Cells Translational Medicine·Mereena George UshakumaryAnne-Karina T Perl

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