Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism

Biochimica Et Biophysica Acta. Reviews on Cancer
Michael S DahabiehSonia V Del Rincón

Abstract

Cancer is irrevocably linked to aberrant metabolic processes. While once considered a vestigial organelle, we now know that peroxisomes play a central role in the metabolism of reactive oxygen species, bile acids, ether phospholipids (e.g. plasmalogens), very-long chain, and branched-chain fatty acids. Immune system evasion is a hallmark of cancer, and peroxisomes have an emerging role in the regulation of cellular immune responses. Investigations of individual peroxisome proteins and metabolites support their pro-tumorigenic functions. However, a significant knowledge gap remains regarding how individual functions of proteins and metabolites of the peroxisome orchestrate its potential role as a pro-tumorigenic organelle. This review highlights new advances in our understanding of biogenesis, enzymatic functions, and autophagic degradation of peroxisomes (pexophagy), and provides evidence linking these activities to tumorigenesis. Finally, we propose avenues that may be exploited to target peroxisome-related processes as a mode of combatting cancer.

Citations

Dec 10, 2019·Cell Biology International·Marta Ortega-MartínezGilberto Jaramillo-Rangel
Jul 2, 2020·Cancers·Dilip NarayananDennis Özcelik
Jul 18, 2020·Cells·Jung-Ae Kim
May 28, 2019·Molecular & Cellular Oncology·Victoria RiccioPeter Kijun Kim
Aug 7, 2019·International Journal of Molecular Sciences·Ana Rita FerreiraDaniela Ribeiro
Aug 11, 2019·International Journal of Molecular Sciences·Francesca Di CaraStéphane Savary
Aug 1, 2019·Current Topics in Medicinal Chemistry·Anatoly SorokinEugene Nikolaev
Jan 21, 2021·European Journal of Medical Research·Qiu ZhengqiAo Ying
Jan 9, 2021·Cancer & Metabolism·Shilpa R NagarajanAndrew J Hoy
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Paula DíazSergio Lavandero
May 14, 2021·Developmental Cell·Archna RaviBrooke M Emerling
Jul 15, 2021·Journal of Toxicology and Environmental Health. Part a·Nelzi Ferreira Queiroz JuniorFrancine Carla Cadoná
Aug 8, 2021·International Journal of Molecular Sciences·Malin Tordis MeyerSrikanth Karnati

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