Peroxyl radical clocks

The Journal of Organic Chemistry
Bill RoschekNed A Porter

Abstract

A series of peroxyl radical clocks has been developed and calibrated based on the competition between the unimolecular beta-fragmentation (k(beta)) of a peroxyl radical and its bimolecular reaction with a hydrogen atom donor (k(H)). These clocks are based on either methyl linoleate or allylbenzene and were calibrated directly with alpha-tocopherol or methyl linoleate, which have well-established rate constants for reaction with peroxyl radicals (k(H-tocopherol) = 3.5 x 10(6) M(-1) s(-1), k(H-linoleate) = 62 M(-1) s(-1)). This peroxyl radical clock methodology has been successfully applied to determine inhibition and propagation rate constants ranging from 10(0) to 10(7) M(-1) s(-1).

References

Apr 1, 1995·Lipids·N A PorterK A Mills
Nov 22, 2001·Journal of the American Chemical Society·K A TallmanN A Porter
Mar 1, 2003·The Journal of Organic Chemistry·Riccardo AmoratiLucedio Greci
Jul 30, 2004·Journal of the American Chemical Society·Keri A TallmanNed A Porter

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Citations

Aug 25, 2011·Chemical Reviews·Huiyong YinNed A Porter
Apr 1, 2009·Journal of the American Chemical Society·Keri A TallmanNed A Porter
Aug 27, 2009·Journal of the American Chemical Society·Libin XuNed A Porter
Feb 4, 2010·Journal of the American Chemical Society·Libin XuNed A Porter
Mar 1, 2008·Chemical Communications : Chem Comm·Mukund Jha, Derek A Pratt
Jun 19, 2012·Free Radical Biology & Medicine·Shauna HillMikhail S Shchepinov
Dec 17, 2014·Free Radical Research·R Amorati, L Valgimigli
Mar 30, 2016·Journal of the American Chemical Society·Evan A HaidaszDerek A Pratt
May 26, 2007·Chemistry & Biology·Claus SchneiderAlan R Brash
Feb 11, 2015·Free Radical Biology & Medicine·Bo Li, Derek A Pratt
Jul 19, 2014·Journal of the American Chemical Society·William N BeaversNed A Porter
Dec 2, 2014·Organic & Biomolecular Chemistry·H MuchalskiN A Porter
Mar 30, 2011·Organic & Biomolecular Chemistry·Philip T LynettDerek A Pratt
Nov 2, 2011·Organic & Biomolecular Chemistry·Tae-gyu NamByeong-Seon Jeong
Aug 4, 2020·Bioorganic Chemistry·Chhabi Lal ChaudharyByeong-Seon Jeong
Nov 4, 2008·The Journal of Organic Chemistry·Susheel J NaraDerek A Pratt
Nov 5, 2011·The Journal of Organic Chemistry·Jason J Hanthorn, Derek A Pratt
Mar 15, 2014·Journal of the American Chemical Society·Libin Xu, Ned A Porter
Dec 24, 2014·Journal of the American Chemical Society·Hubert MuchalskiNed A Porter

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