Peroxyl radical scavenging activity of the antihypertensive drug carvedilol

Toxicology in Vitro : an International Journal Published in Association with BIBRA
O I Aruoma

Abstract

The antihypertensive drug carvedilol was tested for its ability to scavenge peroxyl radicals by use of the model radical trichloromethyl peroxyl (CC1(3)O(2)). Carvedilol scavenged CC1(3)O(2) with a calculated rate constant of 1.5 +- 0.1 x 10(7)/M(-1) sec(-1). This ability to react rapidly with peroxyl radicals might be one mechanism by which carvedilol inhibits lipid peroxidation accounting for its reported antioxidant activity.

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·M R BristowB Müller-Beckmann
Feb 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O I AruomaJ Löligers
Aug 1, 1992·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R Dargel
Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Jan 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L SpeyerM Meyers
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Dec 1, 1991·The Journal of Clinical Investigation·J L Witztum, D Steinberg
Oct 1, 1990·Journal of Molecular and Cellular Cardiology·W B WeglickiM G Simìc
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Nov 1, 1988·International Journal of Radiation Biology·M LalK D Asmus
Feb 20, 1986·The New England Journal of Medicine·R Ross
Aug 15, 1984·The Biochemical Journal·T F Slater
Apr 1, 1995·Lipids·N A PorterK A Mills
Aug 6, 1994·Lancet·J D Swales
Sep 30, 1994·Biochemical and Biophysical Research Communications·E LupoW Vetter
Oct 1, 1993·Critical Reviews in Oncology/hematology·M U Dianzani
Jan 14, 1994·European Journal of Pharmacology·T L YueG Z Feuerstein
Jan 1, 1993·Chemical Research in Toxicology·T A Dix, J Aikens
Oct 1, 1995·Current Opinion in Lipidology·C F EbenbichlerJ R Patsch
Jan 1, 1996·Free Radical Biology & Medicine·O I Aruoma

❮ Previous
Next ❯

Citations

Aug 26, 1998·Progress in Cardiovascular Diseases·G FeuersteinR R Ruffolo
Nov 21, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·E SánchezG Castellano
Sep 21, 2006·Free Radical Research·Piotr SzajerskiStefan Chłopicki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.