Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring

Analytical Chemistry
Dandan LiFan Zhang

Abstract

Drug-induced hepatotoxicity represents an important challenge for safety in drug development. The production of peroxynitrite (ONOO-) is proposed as an early sign in the progression of drug-induced hepatotoxicity. Currently, reported ONOO- probes mainly emit in the visible range or the first NIR window, which have limited in vivo biosensing application due to the autofluorescence and photon scattering. Herein, we developed a peroxynitrite activatable second near-infrared window (NIR-II) molecular probe for drug-induced hepatotoxicity monitoring, based on the fusion of an NIR-II fluorescence turn-on benzothiopyrylium cyanines skeleton and the phenyl borate. In the presence of ONOO-, the probe IRBTP-B can turn on its NIR-II fluorescence by yielding its fluorophore IRBTP-O and display good linear response to ONOO-. Tissue phantom study confirmed reliable activated signals could be acquired at a penetration depth up to 5 mm. Using this probe, we disclose the upregulation of ONOO- in a preclinical drug-induced liver injury model and the remediation with N-acetyl cysteine (NAC) in vivo. We expect that this strategy will serve as a general method for the development of an activatable NIR-II probe based on the hydroxyl functionalized r...Continue Reading

References

May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·C SzabóE Kun
Aug 2, 2003·The New England Journal of Medicine·William M Lee
Mar 15, 2005·Nature Biotechnology·Vasilis NtziachristosRalph Weissleder
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·B Kevin ParkDominic P Williams
May 3, 2005·Nature Reviews. Drug Discovery·Daniel C Liebler, F Peter Guengerich
May 4, 2006·Journal of the American Chemical Society·Dan YangJian-Gang Shen
Aug 20, 2009·Current Medicinal Chemistry·Stefan RussmannIgnazio Grattagliano
Nov 10, 2009·Nature Nanotechnology·Andrew M SmithShuming Nie
Jan 8, 2011·Annual Review of Pharmacology and Toxicology·John S Walsh, Gerald T Miwa
Mar 17, 2012·Angewandte Chemie·Michael Schäferling
Sep 18, 2012·Journal of the American Chemical Society·Quanjuan ZhangYoujun Yang
Dec 1, 2012·Journal of the American Chemical Society·Naama Karton-LifshinDoron Shabat
Aug 21, 2014·Angewandte Chemie·Hoon HyunHak Soo Choi
Nov 26, 2015·Nature Materials·Alexander L AntarisHongjie Dai
Apr 22, 2017·Journal of the American Chemical Society·Qianglu LinJeffrey M Pietryga
Aug 15, 2017·Angewandte Chemie·Emily D CoscoEllen M Sletten
Nov 2, 2017·Nature·Martin J Schnermann
Nov 10, 2017·Nature Biomedical Engineering·Oliver T BrunsMoungi G Bawendi
Apr 7, 2018·Advanced Functional Materials·Kangquan ShouZhen Cheng
Apr 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jessica A CarrOliver T Bruns
Aug 8, 2018·Nature Nanotechnology·Yong FanFan Zhang
Aug 22, 2018·Theranostics·Shoujun ZhuXiaoyuan Chen
Jan 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yue SunPeter J Stang

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Citations

Feb 29, 2020·Future Medicinal Chemistry·Tao JiangWei Wang
Feb 23, 2020·Frontiers in Bioengineering and Biotechnology·Jie CaoHuanghao Yang
Aug 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yue SunPeter J Stang
Mar 3, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yuhui MenJianhong Wang
Aug 12, 2020·Angewandte Chemie·Zuhai Lei, Fan Zhang
Feb 13, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Huihui SuWeili Zhao
Nov 17, 2020·Chemical Society Reviews·Guangxue FengDan Ding
Jun 13, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Minglu LiChuan Dong
Jun 25, 2021·Chemical Science·Amanda K EastJefferson Chan
Jul 29, 2021·Chemical Communications : Chem Comm·Xiaofan ZhangHuimin Ma
Jan 1, 2021·Accounts of Chemical Research·Dan ChengXiao-Bing Zhang
Aug 14, 2020·Journal of the American Chemical Society·Chunyan LiQiangbin Wang
Sep 3, 2020·ACS Central Science·Shangfeng WangFan Zhang

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