PMID: 8986765Dec 24, 1996Paper

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

Proceedings of the National Academy of Sciences of the United States of America
L M LandinoL J Marnett

Abstract

Peroxynitrite activates the cyclooxygenase activities of constitutive and inducible prostaglandin endoperoxide synthases by serving as a substrate for the enzymes' peroxidase activities. Activation of purified enzyme is induced by direct addition of peroxynitrite or by in situ generation of peroxynitrite from NO coupling to superoxide anion. Cu,Zn-superoxide dismutase completely inhibits cyclooxygenase activation in systems where peroxynitrite is generated in situ from superoxide. In the murine macrophage cell line RAW264.7, the lipophilic superoxide dismutase-mimetic agents, Cu(II) (3,5-diisopropylsalicylic acid)2, and Mn(III) tetrakis(1-methyl-4-pyridyl)porphyrin dose-dependently decrease the synthesis of prostaglandins without affecting the levels of NO synthase or prostaglandin endoperoxide synthase or by inhibiting the release of arachidonic acid. These findings support the hypothesis that peroxynitrite is an important modulator of cyclooxygenase activity in inflammatory cells and establish that superoxide anion serves as a biochemical link between NO and prostaglandin biosynthesis.

References

Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Nov 1, 1992·Chemical Research in Toxicology·W H KoppenolJ S Beckman
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieD L Simmons
Jan 1, 1990·Methods in Enzymology·R OdenwallerL J Marnett
Jan 1, 1989·The American Review of Respiratory Disease·R DworskiG A Fitzgerald
Jan 1, 1986·Annual Review of Biochemistry·P NeedlemanJ B Lefkowith
Mar 25, 1988·Biochimica Et Biophysica Acta·J KuiperT J van Berkel
Jul 1, 1987·Chemistry and Physics of Lipids·F Ursini, A Bindoli
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Dec 20, 1973·Biochimica Et Biophysica Acta·D H Nugteren, E Hazelhof
Jan 1, 1967·The Journal of Pediatrics·L F Hill
Jul 1, 1983·Science·T W KenslerW J Kozumbo
May 1, 1994·The Journal of Clinical Investigation·D SalveminiP Needleman
Jan 1, 1994·Methods in Enzymology·J M Hevel, M A Marletta
Dec 1, 1994·Journal of Leukocyte Biology·T M WizemannD L Laskin
Jan 1, 1995·British Journal of Pharmacology·L SautebinM Di Rosa
Mar 1, 1995·British Journal of Pharmacology·D SalveminiP Needleman
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Nov 15, 1994·The Biochemical Journal·E C Theil
Jan 1, 1994·Methods in Enzymology·J S BeckmanJ P Crow
Sep 1, 1994·Archives of Biochemistry and Biophysics·A L TsaiR J Kulmacz
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja
Jun 1, 1996·British Journal of Pharmacology·D SalveminiM G Currie
Apr 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Di RosaL Sautebin
Jul 1, 1996·Chemical Research in Toxicology·J S Beckman

❮ Previous
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Citations

Jan 16, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andreas ReichenbachAndreas Bringmann
Sep 4, 2009·Archives of Pharmacal Research·Wilmarie Flores-SantanaDavid A Wink
May 19, 2005·Biochemical Pharmacology·Daniel FreinVolker Ullrich
Mar 30, 2004·Biomaterials·Bernard P ChanGeorge A Truskey
Apr 9, 2002·Prostaglandins & Other Lipid Mediators·Chatargy S KazaBasil Rigas
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Nicolas G BazanWalter J Lukiw
Feb 13, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M C Verhaar, T J Rabelink
Apr 20, 2000·Neuroscience·T LiuD J Tracey
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Serafini
Dec 17, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Apr 18, 2002·Free Radical Biology & Medicine·Alison A BeharkaSimin Nikbin Meydani
Jul 20, 2002·Free Radical Biology & Medicine·Ramón Rodrigo, Gonzalo Rivera
Jun 26, 1998·Free Radical Biology & Medicine·D Jang, G A Murrell
Feb 19, 2004·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Marija KusleikaiteSaulius Kusleika
Jul 2, 2003·The Journal of Nutritional Biochemistry·Kiminori MatsubaraNorihisa Kato
Dec 14, 2006·Prostaglandins & Other Lipid Mediators·Rita K UpmacisDavid P Hajjar
Jan 26, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·C BernardeauM Breban
Sep 28, 2000·Current Opinion in Chemical Biology·L J Marnett
Apr 11, 2003·Biochimica Et Biophysica Acta·S KomatsuN Kato
Sep 29, 2011·Chemical Reviews·William L SmithPer-Johan Jakobsson
Mar 4, 2010·Journal of the American Chemical Society·Ruba S DeebDavid P Hajjar
Aug 2, 2007·Nature Reviews. Drug Discovery·Csaba SzabóRafael Radi
Feb 22, 2001·British Journal of Pharmacology·D SalveminiS Cuzzocrea
Feb 19, 2002·Kidney International·Christopher M ReillyGary S Gilkeson

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