Perphenazine decreases vomiting by children after tonsillectomy

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
W M Splinter, D J Roberts

Abstract

To test the hypothesis that perphenazine decreases the incidence of vomiting by children after tonsillectomy. Healthy children (n = 260) aged 2-12 yr undergoing elective tonsillectomy on a day care surgical basis were studied in this randomised. stratified, blocked, double-blind investigation. General Anaesthesia was induced intravenously with propofol or by inhalation with halothane and N2O. Perphenazine 70 micrograms.kg-1 up to 5 mg or placebo i.v. was administered before surgery. Management of perioperative fluids, emesis and pain were all standardised. The groups were similar with respect to demographic data. There was less vomiting after perphenazine during the first 24 hr after surgery 42% (95% CI = 34%-50%) vs 57% (95% CI = 48%-66%, placebo), P < 0.01. On the day of surgery, both in and out-of hospital emesis were decreased by perphenazine. The perphenazine treated patients required fewer rescue antiemetics than the control group, P < 0.05. Each episode of in-hospital vomiting delayed discharge by 20 +/- 7 min (mean +/- SD), P = 0.007. The prophylactic administration of perphenazine decreases vomiting by children after tonsillectomy.

References

Mar 1, 1973·The British Journal of Oral Surgery·A J Smith
Nov 1, 1970·Anesthesia and Analgesia·J A Aldrete, D Kroulik
Apr 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W M SplinterL Komocar
Mar 1, 1994·Anesthesia and Analgesia·R S LitmanF A Catanzaro
Oct 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W M SplinterH B MacNeill
Jan 1, 1997·Paediatric Anaesthesia·N S MortonL A Cohen

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Citations

Oct 24, 2003·International Anesthesiology Clinics·Olutoyin Olutoye, Mehernoor F Watcha
Aug 27, 2010·European Journal of Anaesthesiology·Alexander SchnabelPeter Kranke
Oct 23, 2002·Paediatric Drugs·Pasquale De Negri, Giorgio Ivani
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson

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