Perphenazine for schizophrenia.

The Cochrane Database of Systematic Reviews
B HartungStefan Leucht

Abstract

Perphenazine is an old phenothiazine antipsychotic with a potency similar to haloperidol. It has been used for many years and is popular in the northern European countries and Japan. To examine the clinical effects and safety of perphenazine for those with schizophrenia and schizophrenia-like psychoses. We updated our original search using the Cochrane Schizophrenia Group's register (September 2013), references of all included studies and contacted pharmaceutical companies and authors of included studies in order to identify further trials. We included all randomised controlled trials that compared perphenazine with other treatments for people with schizophrenia and/or schizophrenia-like psychoses. We excluded trials of depot formulations of perphenazine. Two review authors independently inspected citations and, where possible, abstracts. We ordered papers, inspected and quality assessed them. We extracted data, again working independently. If loss to follow-up was greater than 50% we considered results as 'prone to bias'. For dichotomous data, we calculated risk ratios (RR) and for continuous data we calculated mean differences (MD), both with the 95% confidence intervals (CI). We assessed quality of data using the GRADE (Grad...Continue Reading

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Citations

Apr 29, 2016·The Cochrane Database of Systematic Reviews·Selin Nur, Clive E Adams
Dec 15, 2020·Drug Development and Industrial Pharmacy·Parnian MohammadiMohammad Mehdi Mahboobian

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