Persistence and transition of Epstein-Barr virus genotypes in the pathogenesis of oral hairy leukoplakia

The Journal of Infectious Diseases
Dennis M WallingC Mark Nichols

Abstract

This prospective study examined the persistence and transition of Epstein-Barr virus (EBV) in human immunodeficiency virus (HIV)-seropositive subjects with and without oral hairy leukoplakia, a replicative EBV-associated epithelial disease. The intrahost molecular epidemiology of EBV infection was characterized in subjects treated with valacyclovir to suppress EBV replication. Tongue epithelial tissues of HIV-seropositive subjects were found to support not only EBV replication but also persistent, nonproductive EBV infection. EBV appeared to enter the tongue from the blood reservoir of infection and, possibly, from exogenous sources as well. EBV transition from the blood to the tongue appeared to occur even during valacyclovir-mediated suppression of EBV replication, suggesting EBV entry into tongue epithelial tissue as a cell-associated latent infection. In conclusion, these results describe the persistence and transition of EBV as a dynamic interaction between the blood and epithelial reservoirs of EBV infection and suggest a role for entry, persistence, and reactivation of oral epithelial EBV in the pathogenesis of oral hairy leukoplakia.

Citations

Nov 22, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
May 31, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Lertlakana BhoopatTanin Bhoopat
Mar 1, 2008·Head and Neck Pathology·Paulo Henrique Braz-SilvaMarina Helena Cury Gallottini de Magalhães
Jan 27, 2009·Journal of Endodontics·Vicky ChenCurtis A Machida
Apr 6, 2016·International Journal of Dentistry·Razia Abdool Gafaar KhammissaLiviu Feller
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Dec 3, 2010·Journal of Cutaneous Pathology·Erica C RushingSteven D Billings
Jan 1, 2012·Pathogens·Stelios Tzellos, Paul J Farrell
Mar 22, 2018·Cancers·Kathy H Y ShairVaughn S Cooper

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