Persistence assessment of cyclohexyl- and norbornyl-derived ketones and their degradation products in different OECD screening tests

Chemosphere
Markus SeyfriedA Chaintreau

Abstract

The persistence of synthetic cyclohexyl- and norbornyl-derived ketones was assessed by using OECD 301F and 301D biodegradation tests. While cyclohexyl-derived ketones either reached or came close to the pass level (60%) after 60 d, the corresponding norbornyl derivatives yielded significantly less biodegradation (<40%). By analyzing extracts at 60 d, the key degradation products of four norbornyl derivatives were identified. Consistently, 2-bicyclo[2.2.1]heptane carboxylic acid was found as a principal degradation product with minor quantities of bicyclo[2.2.1]heptan-2-one and 2-bicyclo[2.2.1]heptane acetic acid. When the three degradation products were re-synthesized and tested individually for biodegradability, the former two were found to be ultimately biodegradable after 60 d in OECD 301D tests, thus proving non-persistence. Similarly, 2-bicyclo[2.2.1]heptane acetic acid was found to be degraded significantly, albeit with long lag phases exceeding 60 d in the case of freshwater inoculum, then ultimately reaching the pass level. On the other hand, norbornyl ketones were still only partially biodegradable in the same test. We conclude that despite the potential for ultimate biodegradation of norbornyl-derived ketones, current...Continue Reading

References

Dec 1, 1992·Ecotoxicology and Environmental Safety·C G van Ginkel, C A Stroo
Oct 1, 1984·Ecotoxicology and Environmental Safety·N NyholmN Hansen
Apr 1, 1996·Ecotoxicology and Environmental Safety·G ThouandJ C Block
Apr 3, 2001·Applied and Environmental Microbiology·T K Dutta, S Harayama
Feb 10, 2011·Environmental Toxicology and Chemistry·Karen J JennerPhilippe Racine
Apr 14, 2011·Nucleic Acids Research·Junfeng GaoLawrence P Wackett

❮ Previous
Next ❯

Citations

May 19, 2021·Environmental Toxicology and Chemistry·Ryosuke NabeokaTomohiko Yoshida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.