Persistence of androgenic effects on the production of proinflammatory cytokines by circulating antigen-presenting cells after withdrawal of testosterone treatment in aging type 2 diabetic men with partial androgen deficiency

Fertility and Sterility
J J CorralesA Orfao

Abstract

To test the hypothesis that T treatment withdrawal could be associated with an enhancement of proinflammatory cytokine production by peripheral blood monocytes and dendritic cells. A prospective intervention study. Tertiary university hospital. Thirteen type 2 diabetic men aged >55 years with partial androgen deficiency and eight age-matched healthy men (controls). Analyses were performed before and 12 months after T replacement therapy and the results compared with those obtained for the same patients after a 3-month T withdrawal period. Distribution of circulating T, B, and natural killer lymphocytes, monocytes, and CD33(hi) myeloid, CD16+, and plasmacytoid dendritic cell subsets. Spontaneous and stimulated ex vivo production of inflammatory cytokines (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha) by circulating monocytes and dendritic cells, which represent the most potent antigen-presenting cells. The reduction or complete abrogation of spontaneous ex vivo production of proinflammatory cytokines by monocytes and dendritic cells observed after 12 months of T replacement therapy was maintained 3 months after T withdrawal. These are the first results showing that exogenous T treatment deprivation is not as...Continue Reading

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Citations

Jan 9, 2016·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aksam YassinGheorge Doros
Sep 11, 2012·European Journal of Clinical Investigation·Juan J CorralesAlberto Orfao
Feb 25, 2015·Cellular Immunology·Abhishek TrigunaiteTrine N Jørgensen
Jun 22, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Nur-Vaizura MohamadKok-Yong Chin
Jan 11, 2018·Endocrine-related Cancer·Clovis Boibessot, Paul Toren
Dec 26, 2018·Journal of the Endocrine Society·Vittorio Emanuele Bianchi
Jun 9, 2018·International Journal of Molecular Sciences·Jonatan LefflerDeborah H Strickland
Dec 19, 2018·Journal of Clinical Medicine·Abdulmaged TraishAbraham Morgentaler
May 15, 2018·Frontiers in Immunology·Melanie R Gubbels Bupp, Trine N Jorgensen
Feb 23, 2021·Reviews in Endocrine & Metabolic Disorders·Baris GencerMassimiliano Ruscica
Feb 23, 2020·Neurobiology of Disease·Lei YangXiaoqiang Liu

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