Persistence of antibodies to hepatitis C virus in a chronic hemodialysis population

Nephron
F CarreraC Pires

Abstract

In order to evaluate the persistence of antibodies against hepatitis C virus (HCV) in a chronic hemodialysis population, we studied 151 HBsAg-negative patients. Anti-HCV titers were evaluated every 3 months over 1 year, and the serum alanine aminotransferase/serum aspartate aminotransferase ratio monthly from the start of hemodialysis. The anti-HCV titers (ELISA C100-3) remained stable in 127 patients and fluctuated in 24, without an evident correlation with hepatic function. Using our criteria, we found 85 patients with non-A, non-B hepatitis, 57 of them with biochemical criteria of chronic hepatic disease. There was a strong correlation between antibodies to HCV and non-A, non-B hepatitis (chi 2; p < 0.05) which was more marked in those patients with biochemical criteria of chronic hepatic disease (chi 2; p < 0.001). We concluded that the anti-HCV titer is reliable as a long-term marker of hepatitis C virus infection.

Citations

Apr 1, 1997·Kidney International·B J Pereira, A S Levey
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FabriziF Locatelli
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FabriziG Gitnick
Jul 28, 2004·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Motoko TanakaKimio Tomita
Jun 30, 2006·International Journal of Clinical Practice·S OcakI Emir
Feb 9, 2005·Diagnostic Microbiology and Infectious Disease·Essam M ElsawyMohamed A Ghoneim
Apr 24, 2010·Néphrologie & thérapeutique·Karima BoubakerAdel Kheder
Oct 19, 2002·Memórias do Instituto Oswaldo Cruz·Solange U BusekGuilherme C Oliveira
Jan 6, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F FabriziG Gitnick

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