Persistence of bronchial reactivity to occupational agents after removal from exposure and identification of associated factors

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Catherine Lemière

Abstract

To examine the outcome of specific bronchial reactivity to occupational agents in patients with occupational asthma who have been removed from exposure to the offending agents and to identify risk factors for the persistence of specific bronchial reactivity. A PubMed (National Library of Medicine) search of articles published from January 1, 1985, through December 31, 2001, with the keywords occupational asthma and bronchial reactivity was performed. This article represents a synthesis of these PubMed sources and the opinion of the author. Specific bronchial reactivity persists in most cases even a long time after removal from exposure to the offending agents. This condition does not seem to be correlated with the persistence of bronchial reactivity to methacholine but seems to be related to the persisting level of specific IgE to the occupational agents in the case of high-molecular-weight agents and platinum salts. Patients who have been diagnosed as having occupational asthma are at risk of developing an asthmatic reaction in the minutes following re-exposure to the offending agent, even if they no longer experience asthma symptoms, have normalized their bronchial reactivity, and have not been exposed to the offending agent ...Continue Reading

References

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Citations

Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Dec 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Tracy StoughtonTimothy Craig
Nov 6, 2007·The Journal of Allergy and Clinical Immunology·Jeroen A J VanoirbeekPeter H M Hoet
Jun 25, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X D ZhangP D Siegel
Dec 7, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Salik HussainPeter H M Hoet
Mar 15, 2005·Current Opinion in Allergy and Clinical Immunology·Jacques Ameille, Alexis Descatha
Apr 25, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A BrantP Cullinan
Mar 28, 2009·Current Opinion in Allergy and Clinical Immunology·Kim L LavoieSimon L Bacon

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