Persistence of CD34 Stem Marker in Human Lipoma: Searching for Cancer Stem Cells

International Journal of Biological Sciences
Barbara ZavanGiuseppe A Ferraro

Abstract

Lipomas are benign solid tumours that develop in soft tissues with origin in mesenchymal progenitors. Macroscopically, they appear as soft-elastic nodules, varying in volume from a few millimiters to several centimetres and can enlarge progressively. Although they are usually asymptomatic, they can cause symptoms due to nerve or vessel compression. Microscopically they appear as fibrous connective tissue stroma with embedded adipocytes, and absence of inflammation. Up to now no characterisation of stem cell population present in this tissue has been performed. Cytofluorimetric, biological and molecular biology analyses have been performed in order to test superficial cell markers and gene expression profile related to stemness and apoptotic activity of cells present in lipoma tissues compared to those of adipose tissue's cells. Our results confirmed that CD34(+) cells in lipoma were present around small adipocytes, showing several altered biological activity such as proliferation, apoptotis and stemness. The data emerging from the comparison of the lipoma cells and normal adipose tissue, suggests the presence of cell precursors involved in the development of the lipoma. This hypothesis requires further investigation and may ind...Continue Reading

Citations

Dec 13, 2019·Stem Cells International·Takahiro TeshimaHidekazu Koyama
Jul 25, 2017·Journal of Comparative Pathology·R FurumotoK Takahashi
Nov 21, 2021·BMJ Case Reports·Kathleen Renee LundebergJulie Randolph-Habecker

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Methods Mentioned

BETA
flow cytometry
enzyme‑linked immunosorbent assay
light microscopy
Profiler
PCR

Software Mentioned

Excel Data Analysis
SPSS

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