PMID: 11912459Mar 26, 2002Paper

Persistence of Chlamydia trachomatis infection detected by polymerase chain reaction in untreated patients

Sexually Transmitted Diseases
James L JoynerFranklyn N Judson

Abstract

Prior studies have used Chlamydia trachomatis culture methods to demonstrate both persistence and spontaneous clearance of genital C trachomatis infection. To further assess the issue of persistence and spontaneous clearance of C trachomatis infection, untreated men and women were evaluated with repeated polymerase chain reaction (PCR) testing. Ninety four untreated patients with a prior positive C trachomatis PCR test returning to the Denver Metro Sexually Transmitted Disease Clinic were retested by PCR. The median and range intervals from initial to follow-up testing were 9.0 (2-112) days for men and 10.0 (2-231) days for women. Repeated PCR tests were positive for 29 of 36 men (80.6%) and 45 of 58 women (77.6%). Persistent PCR positivity did not decrease with a longer testing interval. By multivariate analysis, independent predictors of a persistently positive PCR test included nonwhite ethnicity, an interval of more than 3 days since last sexual encounter before the initial test, and an initial PCR optical density value of greater than or equal to 3.0. In the absence of treatment, a large majority of patients testing positive for C trachomatis by PCR are likely to remain positive for variable periods of time, increasing the...Continue Reading

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Citations

Jul 10, 2003·The Journal of Infection·Whitney Greene, Guangming Zhong
Dec 20, 2002·Seminars in Pediatric Infectious Diseases·Margaret R Hammerschlag
Jun 5, 2010·The Journal of Infectious Diseases·Byron E BatteigerMichael L Rekart
Jul 21, 2009·Sexually Transmitted Diseases·Patricia J KissingerDavid H Martin
Sep 22, 2006·Infection and Immunity·Zarine R BalsaraMichael N Starnbach
Dec 23, 2003·Infection and Immunity·Whitney GreeneGuangming Zhong
Nov 1, 2005·Women's Health·Jane Norman
Mar 9, 2013·The Journal of Infectious Diseases·William M GeislerEdward W Hook
Feb 16, 2008·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Alia A Al-TayyibRichard E Rothman
Mar 24, 2016·Health Technology Assessment : HTA·Malcolm J PricePaddy J Horner
Jun 25, 2014·Frontiers in Cellular and Infection Microbiology·Maria E LewisAlison J Quayle
Jan 26, 2016·PloS One·Edith Margarita Quinónez-CalvacheManuel Alfonso Patarroyo
Mar 18, 2017·Epidemiology·Joanna Lewis, Peter J White
Dec 29, 2010·International Journal of STD & AIDS·E LanjouwW I van der Meijden
Nov 6, 2015·International Journal of STD & AIDS·Nneka C NwokoloKeith Radcliffe
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Aug 25, 2007·Sexually Transmitted Diseases·Christopher K FairleyJane S Hocking
Apr 16, 2010·Sexually Transmitted Diseases·Senu K ApewokinLaura H Bachmann
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Jul 20, 2019·Sexually Transmitted Infections·Hanna ÖhmanHeljä-Marja Surcel
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wendy P Loomis, Michael N Starnbach
Feb 19, 2020·Sexually Transmitted Infections·Nicole H T M Dukers-MuijrersPetra F G Wolffs
Jan 26, 2021·Sexually Transmitted Diseases·Kristen M KreiselIan H Spicknall

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