Persistence of concordant luteinizing hormone (LH), testosterone, and alpha-subunit pulses after LH-releasing hormone antagonist administration in normal men

The Journal of Clinical Endocrinology and Metabolism
S N PavlouD J Stallard

Abstract

LHRH antagonists suppress pituitary and gonadal function by competing with endogenous LHRH for binding to gonadotroph receptors. To determine the mechanism of suppression of gonadotropin secretion we studied the effects of a single dose of a LHRH antagonist on the pulsatile activity of serum bioactive LH (Bio-LH), immunoreactive LH (IR-LH), alpha-subunit, and testosterone for 24 h in normal men. The LHRH antagonist, Nal-Glu [( Ac-D2Nal1,D4ClPhe2,D3Pal3,Arg5,DGlu6-(AA), DAla10]LHRH) was given as a single sc injection of 5 mg to five normal men. Blood samples were collected every 10 min during a 10-h baseline period and for 14 h after administration of the antagonist. IR-LH, alpha-subunit, and testosterone were measured in triplicate, and Bio-LH in duplicate. Pulses were then evaluated using Cluster analysis; all replicates were entered in the pulse analysis. After administration of the Nal-Glu antagonist, IR-LH levels decreased (P less than 0.001) from 2.81 +/- 0.06 at baseline to a nadir of 0.75 +/- 0.02 U/L. Bio-LH levels followed the same pattern, decreasing by 89% (P less than 0.001) from 4.54 +/- 0.13 to a nadir of 0.51 +/- 0.13 U/L 6.8 h after the injection of Nal-Glu. In contrast, serum alpha-subunit levels did not change...Continue Reading

Citations

Jun 30, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A CanoC Armero
Oct 21, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisThomas Mulligan
Dec 2, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisChristina Wang
Apr 1, 1992·Contraception·K GordonG D Hodgen
May 14, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter Y LiuJohannes D Veldhuis
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D M Keenan, J D Veldhuis

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