Persistence of distal motor control in the locked in syndrome. Review of 11 patients

Paraplegia
I RichardJ F Mathe

Abstract

We report 11 patients with the locked in syndrome (LIS). The functional outcome was good in four patients with notable motor recovery, but motor deficit remained seriously disturbed in seven patients. All of the patients regained some distal control of finger and toe movements, often allowing functional use of a digital switch. The independence thereby gained is worthwhile, in some patients allowing environment control, communication by means of a computer, and electric wheelchair ambulation. When motor recovery occurs, the progression is disto-proximal with dramatic axial hypotonia. In five patients clinical insomnia was noted and polysomnography showed a reduction of REM sleep. The implications of systems other than the pyramidal tracts in the physiopathology of LIS are discussed.

References

Aug 1, 1977·Electroencephalography and Clinical Neurophysiology·J L Cummings, R Greenberg
Aug 1, 1979·Journal of Neurology·G BauerE Rumpl
Aug 1, 1976·Neurology·O N Markand, M L Dyken
Apr 1, 1991·Electroencephalography and Clinical Neurophysiology·A OksenbergI Reider-Groswasser
Dec 1, 1991·Scandinavian Journal of Dental Research·J Ribeiro, D Ericson
Jan 1, 1990·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J M Siegel
Mar 27, 1989·Neuroscience Letters·E Schenkel, J M Siegel
Nov 1, 1989·The American Journal of Emergency Medicine·U E Gallo, P B Fontanarosa
Jan 1, 1988·Annales Françaises D'anesthèsie Et De Rèanimation·J L DelacourA Noirot
Jan 24, 1987·British Medical Journal·J M Pearce
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·J R Patterson, M Grabois
Feb 1, 1973·Electroencephalography and Clinical Neurophysiology·C GuilleminaultP Castaigne
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Nov 16, 1974·British Medical Journal·C H Hawkes
Jan 1, 1984·Clinical Neurology and Neurosurgery·R S Virgile
Apr 6, 1984·Neuroscience Letters·J M SiegelK S Tomaszewski
Jul 1, 1983·Journal of the Neurological Sciences·M Reznik
Jan 1, 1982·Annals of Neurology·P LarmandeA Gouazé
Mar 1, 1982·Archives of Neurology·E A McCuskerR C Griggs
Apr 1, 1994·Neurophysiologie clinique = Clinical neurophysiology·B Lannes, G Micheletti

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Citations

Mar 14, 2013·QJM : Monthly Journal of the Association of Physicians·J S BalamiA M Buchan
Feb 19, 2005·BMJ : British Medical Journal·Eimear Smith, Mark Delargy
Jul 28, 2011·Neurosurgery·Cara L SedneyJulian E Bailes
Jul 17, 2015·Brain Injury : [BI]·Zulay R LugoSteven Laureys
May 25, 2013·The American Journal of Emergency Medicine·Corey GoldbergChristopher Hopkins
Sep 15, 2009·Pediatric Neurology·Marie-Aurélie BrunoSteven Laureys
Apr 29, 2008·Revue neurologique·M-A BrunoS Laureys
Jun 17, 2003·Archives of Physical Medicine and Rehabilitation·Emanuela CasanovaAnna Mazzucchi
Feb 12, 2005·Archives of Physical Medicine and Rehabilitation·Peter W New, Sonia J Thomas
Jan 20, 2021·PM & R : the Journal of Injury, Function, and Rehabilitation·Ellen FarrRichard L Harvey

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