Persistence of functionally compromised anti-double-stranded DNA B cells in the periphery of non-autoimmune mice

International Immunology
J H RoarkJ Erikson

Abstract

Both anti-single-stranded (ss) and anti-double-stranded (ds) DNA antibodies are associated with the autoimmune disease systemic lupus erythematosus (SLE), but only anti-dsDNA antibodies are considered one of the diagnostic criteria. Using Ig transgenes coding for anti-DNA we have determined the fate of anti-dsDNA B cells in a non-autoimmune environment. In a Rag-2 wild-type background, B cells expressing the anti-dsDNA Ig transgenes are present in the spleen but dsDNA specificity is disrupted due to expression of endogenous L chains. In a Rag-2-deficient background where co-expression of endogenous Ig is blocked, splenic B cells expressing only the anti-dsDNA transgene Ig are present, indicating that endogenous Ig expression is not required for bone marrow export. The anti-dsDNA B cells that persist are profoundly crippled in that they are unable to proliferate to lipopolysaccharide or anti-Ig stimulation. Furthermore, these anti-dsDNA Ig transgene B cells show a decreased lifespan relative to non-transgene BALB/c B cells. Persistence of anti-dsDNA B cells in the periphery of non-autoimmune mice raises the possibility that their appearance in the context of SLE is due to their reactivation by T cell help.

Citations

Feb 28, 1998·Immunologic Research·J EriksonJ H Roark
Nov 25, 2003·Current Opinion in Immunology·Michele L Fields, Jan Erikson
Jul 21, 2007·Nature Reviews. Immunology·John C CambierBarbara J Vilen
Sep 8, 1999·The Journal of Experimental Medicine·H Wang, M J Shlomchik
Oct 8, 2005·The Journal of Clinical Investigation·Amedeo CappioneIñaki Sanz
Jan 1, 2014·European Journal of Immunology·Greg A KirchenbaumLawrence J Wysocki
Jul 14, 2009·Molecular Immunology·Nichol E HolodickThomas L Rothstein
Mar 26, 2005·Immunological Reviews·Michele L FieldsJan Erikson
Aug 24, 2010·Immunological Reviews·Yuval YarkoniJohn C Cambier
Feb 6, 2007·Seminars in Immunology·Sean R Christensen, Mark J Shlomchik
Jun 19, 2013·International Reviews of Immunology·Laurens P Kil, Rudi W Hendriks
Sep 25, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Y ChoiJ M Puck
Sep 20, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin NündelAnn Marshak-Rothstein
Dec 29, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Holly R SteachJustin J Taylor
Oct 9, 1998·The Journal of Experimental Medicine·H XuM Weigert
May 30, 2020·Immunological Reviews·Jackson S TurnerIrina L Grigorova
Jul 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yao ChenLaurent Verkoczy
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle Borrero, Stephen H Clarke
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donna A CultonStephen H Clarke
Apr 10, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Corey TanJulie Zikherman
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L Mandik-NayakD D Chaplin
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gayle C BosmaMelvin J Bosma
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P Cancro, John F Kearney
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M L FieldsJ Erikson
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lenka YunkEline T Luning Prak
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ramiro DizStephen H Clarke
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tâm D QuáchIñaki Sanz
Feb 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie-Yu ChungFrank Alderuccio
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michele L FieldsJan Erikson

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