Persistence of glutamic acid decarboxylase antibody (GADA) is associated with clinical characteristics of latent autoimmune diabetes in adults: a prospective study with 3-year follow-up

Diabetes/metabolism Research and Reviews
Gan HuangZhi-guang Zhou

Abstract

Latent autoimmune diabetes in adults (LADA) is a form of autoimmune diabetes with heterogeneous features. This study aimed to investigate the persistent status of glutamic acid decarboxylase antibody (GADA) in patients with LADA and its association with clinical characteristics. This 3-year follow-up study enrolled 107 LADA and 40 type 2 diabetes mellitus (T2DM) patients from October 2005 to December 2013. GADA titer, epitopes, and clinical characteristics (including fasting C-peptide and HbA1c ) in LADA patients were assayed annually. The human leukocyte antigen DQ (HLA-DQ) genotypes were also analysed. The relationship between the persistence of GADA and the clinical characteristics was investigated in LADA patients. After 3-year follow-up, 36.5% (39/107) LADA patients remained GADA positive (persistently positive group), 19.6% (21/107) patients fluctuated positively and negatively (fluctuating group), and 43.9% (47/107) patients became GADA negative, among which 61.7% (29/47) seroconversions occurred within 6 months of follow-up (transiently positive group). The GADA persistently positive group possessed higher titer of GADA than transiently positive group and fluctuant group (all p = 0.000), higher reactivities to middle an...Continue Reading

References

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Citations

Jul 28, 2016·Current Diabetes Reports·Jakob Appel ØstergaardR David Leslie
Apr 27, 2018·Diabetes/metabolism Research and Reviews·Jacob V StidsenHenning Beck-Nielsen
Jul 31, 2018·Current Diabetes Reviews·Elin Pettersen Sørgjerd
Apr 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Xia LiZhiguang Zhou
May 8, 2020·Immunity, Inflammation and Disease·Christiane S HampeOlov Rolandsson
Apr 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Xia LiZhiguang Zhou
Aug 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Xia LiZhiguang Zhou
May 1, 2021·Diabetes/metabolism Research and Reviews·Mei ShiXia Li
Jun 23, 2021·Diabetes/metabolism Research and Reviews·Juan HuangZhiguang Zhou

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