Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression

Journal of Virology
S A IslamS A Kalams

Abstract

We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection.

References

Jul 23, 1987·Nature·B D WalkerR T Schooley
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·G PantaleoA S Fauci
Dec 22, 1998·The Journal of Experimental Medicine·A J ZajacR Ahmed

❮ Previous
Next ❯

Citations

Aug 6, 2002·Current Opinion in Microbiology·Paul KlenermanRodney Phillips
Aug 4, 2004·The Journal of Experimental Medicine·Dirk Meyer-OlsonSpyros A Kalams
May 14, 2004·Journal of Virology·E John Wherry, Rafi Ahmed
Dec 25, 2002·Journal of Clinical Pathology·E HodgesJ L Smith
Mar 14, 2013·BioMed Research International·Maria Cecilia Garibaldi MarcondesHoward Fox
Nov 12, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Alejandro González-SernaAlejandro Vallejo
Dec 31, 2002·Virology·George B CohenSpyros A Kalams
Mar 24, 2007·Mathematical Biosciences·Dominik Wodarz, Dean H Hamer
May 4, 2004·Nature Reviews. Immunology·Zvi GrossmanWilliam E Paul
Mar 26, 2011·Nature Reviews. Immunology·Arne N Akbar, Sian M Henson
Apr 18, 2003·AIDS·Christian Brander, Yves Rivière
Apr 19, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dirk Meyer-OlsonSpyros A Kalams
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurent DerréNathalie Rufer
Apr 9, 2005·Cell Death and Differentiation·C PetrovasP D Katsikis
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul F McKayNorman L Letvin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.