Persistence of humoral immunity to rabies 1100 days after immunization and effect of a single booster dose of rabies vaccine

Vaccine
R VodopijaI Vodopija

Abstract

Forty-four vaccinees immunized with rabies vaccine and human rabies immunoglobulin according to the abbreviated intramuscular regimen (the 2-1-1 schedule) were followed-up after 1100 days and had their blood samples taken. The persistence of rabies neutralizing antibody was proven in the sera of all vaccinees. 56% of whom demonstrated titres > or = 0.5 IU ml-1. At the same day the vaccinees were given a single booster dose of vaccine whose effect was measured 2 weeks later. With the RFFI test on day 1114, sera revealed an extraordinarily high booster response in all 44 vaccinees. The study proved the anamnestic response after a full course of rabies vaccination to be a very stable one, and the capability of a single booster dose of vaccine to evoke high-titred rabies antibody response. Of the four vaccines used in the study, under comparable conditions HDCV proved superior to PCECV PDEV and PVRV on all 3 days of serology-35, 1100 and 1114, though this difference was statistically attested only on days 35 and 1114.

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Citations

Apr 11, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·C StradyA Strady
Apr 9, 1999·Vaccine·I VodopijaR Vodopija
Nov 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T TantawichienV Sitprija
Feb 17, 2015·Expert Review of Vaccines·Alexandra GiesenClaudius Malerczyk
Nov 7, 2007·Travel Medicine and Infectious Disease·Stephen Toovey
Apr 7, 2005·Vaccine·Amlan GoswamiJean-Antoine Zinsou
Nov 14, 2014·Clinical and Vaccine Immunology : CVI·Jiangping RenZhenyu Gong
Jul 5, 2005·Expert Opinion on Investigational Drugs·D L Lodmell
Apr 17, 2012·Current Opinion in Virology·Deborah J Briggs
May 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Annefleur C LangedijkCornelis Stijnis

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