Persistence of isolated antibodies to woodchuck hepatitis virus core antigen is indicative of occult infection

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Carla S CoffinT I Michalak

Abstract

Antibodies against virus nucleocapsid (anticore) normally accompany hepadnaviral hepatitis but they may also occur in the absence of symptoms and other serological indicators of the infection. This situation can be encountered following a clinically and serologically unapparent exposure to hepatitis B virus (HBV) or after recovery from hepatitis B. In this study, woodchucks inoculated with woodchuck hepatitis virus (WHV) were investigated to determine the relationship between anticore detection and the molecular status of virus replication in a primary WHV surface antigen (WHsAg)-negative infection or long-after resolution of WHV hepatitis. Serial, parallel samples of sera, peripheral blood mononuclear cells (PBMC) and liver tissue, collected for more than 5 years after inoculation with virus, were examined for WHV DNA by highly sensitive polymerase chain reaction (PCR)/nucleic acid hybridization assays. Sera were also tested for WHV DNA after DNase treatment and for WHV DNA and WHsAg after concentration in sucrose. Liver and PBMC were examined for WHV covalently closed circular DNA and viral RNA transcripts by PCR-based techniques to assess virus replication status. The study showed that anticore antibodies existing in the abs...Continue Reading

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Citations

Nov 19, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Simona UrbaniMassimo Franchini
Apr 8, 2011·World Journal of Gastroenterology : WJG·Rocio Aller de la FuenteGregorio Castellano
Apr 8, 2011·World Journal of Gastroenterology : WJG·José Luis LledóSara Ocaña
Apr 30, 2011·World Journal of Gastroenterology : WJG·Zeinab Nabil Ahmed Said
May 31, 2014·World Journal of Gastroenterology : WJG·Teresa Pollicino, Carlo Saitta
Aug 21, 2007·Journal of Medical Virology·Gaia NebbiaAnna Maria Geretti
Apr 5, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carla S CoffinNorah A Terrault
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Nov 17, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Clifford S GuyTomasz I Michalak
Apr 25, 2006·Veterinary Immunology and Immunopathology·Shashi A Gujar, Tomasz I Michalak

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