Persistence of measles antibodies, following changes in the recommended age for the second dose of MMR-vaccine in Portugal

Vaccine
Guilherme GonçalvesMaria São José Nascimento

Abstract

In populations vaccinated with two doses of combined measles-mumps-rubella vaccine (MMR), the serum levels of antibodies against measles depend on the vaccination schedule, time elapsed from the last dose and the area-specific epidemiological situation. Variables measuring "schedule" are age at first and second doses of MMR and intervals derived from that. Changes in vaccination schedules have been made in Portugal. The specific objectives of this study were to measure the association between those potential determinants and the concentration of measles-specific IgG antibodies, after the second dose of MMR. Convenience samples of three Portuguese birth cohorts were selected for this study (41, 66 and 60 born, respectively, in 2001-2003, 1990-1993 and 1994-1995). Geometric mean concentrations (GMC) for measles IgG were, respectively, 934, 251 and 144mIU/ml; p<0.001). Anti-measles-IgG serum concentration decreased with time since last vaccination (waning immunity) and was not influenced by any other component of vaccination schedule, namely age at vaccination with the second dose of MMR. Waning levels of measles antibodies have been observed elsewhere but not as fast as it was observed in Portuguese birth cohorts in this study. C...Continue Reading

References

Jan 1, 1992·Journal of Clinical Laboratory Analysis·H D Dopatka, B Giesendorf
Aug 19, 2007·Vaccine·Corinne VandermeulenHoppenbrouwers Karel
Dec 5, 2008·Expert Review of Vaccines·Guilherme Gonçalves
Jun 17, 2011·The Journal of Infectious Diseases·Amra Uzicanin, Laura Zimmerman
Aug 30, 2013·Expert Review of Vaccines·Felicity T CuttsCharlotte J E Metcalf

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Citations

Mar 5, 2016·Medical Microbiology and Immunology·Heidemarie HolzmannH W Doerr
Jun 18, 2020·International Journal of Environmental Research and Public Health·Jana MalinováAlexander M Čelko
May 24, 2019·Frontiers in Immunology·Mark K Slifka, Ian J Amanna

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