Persistence of newer anti-obesity medications in a real-world setting

Diabetes Research and Clinical Practice
Rahul GangulyWayne Weng

Abstract

Evaluate real-world data on persistence with anti-obesity medications (AOMs) and explore associated patient factors. Truven Health MarketScan® data were analyzed to evaluate utilization of AOMs approved for long-term use between 4/2015 and 3/2016. Kaplan-Meier survival analyses were used to evaluate treatment persistence. A multivariate analysis was performed to identify associations between persistence and relevant factors. In total, 26,522 adult patients were identified as newly prescribed naltrexone/bupropion (44.0%, mean age 47.1, 80.5% female), lorcaserin (24.8%, 48.5, 79.3%), phentermine/topiramate extended release (15.8%, 46.7, 82.2%) or liraglutide 3.0 mg (15.4%, 46.9, 72.4%). At 6 months, 41.8% of patients were still on liraglutide 3.0 mg, compared to 15.9% lorcaserin (p < 0.001), 18.1% naltrexone/bupropion (p < 0.001), and 27.3% phentermine/topiramate (p < 0.001). After adjusting for baseline factors, patients on liraglutide 3.0 mg had significantly lower risk of discontinuation compared to those on lorcaserin (HR = 0.46, p < 0.0001), naltrexone/bupropion (HR = 0.48, p < 0.0001), and phentermine/topiramate (HR = 0.64, p < 0.0001) over the course of follow-up (mean follow-up duration, 342-427 days). Older age, male gen...Continue Reading

Citations

Aug 10, 2019·International Journal of Clinical Practice·Juan J Gorgojo-MartínezFrancisca Almodóvar-Ruiz
Nov 5, 2019·Journal of Attention Disorders·Iraklis Erik TseregounisStephen G Henry
Dec 24, 2019·Obesity·Mina KabiriJames R Baumgardner
Apr 16, 2020·Expert Opinion on Pharmacotherapy·Kishore M Gadde, Katelyn D Atkins
Jan 8, 2021·Current Obesity Reports·Young Jin Tak, Sang Yeoup Lee
Jan 22, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Jung Ha ParkSoo Lim
Aug 24, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Nadia N AhmadHong Kan
Oct 3, 2021·Current Obesity Reports·Ashley J CooperAriana M Chao
Oct 14, 2021·Current Medical Research and Opinion·Andrew OsterlandPaul Godley

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