PMID: 2385960Jun 1, 1990

Persistence of parvovirus H-1 DNA in human B- and T-lymphoma cells

Virus Research
S FaisstH zur Hausen

Abstract

Persisting DNA of parvovirus H-1 could be demonstrated in cells of two human lymphoma cell lines, the Burkitt lymphoma cell line BL2 and the T-cell leukemia cell line Jurkat which survived infection with parvovirus H-1. Persistence of H-1 DNA rendered the cells resistant to a second H-1 infection. This resistance to H-1 superinfection persisted even after loss of H-1 DNA occurring after approximately 150-200 cell generations. Resistance to H-1 superinfection was accompanied by reduced uptake of infectious particles and by a block of H-1 DNA replication. This suggests that persistent H-1 infection leads to modifications of cellular functions involved in the permissivity for H-1.

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Citations

Jan 1, 1991·Archives of Virology·R O JacobyA L Smith
May 1, 1991·Journal of Virological Methods·T W MolitorL R Ludemann
Apr 1, 1993·Virus Research·D J GaertnerJ L Brandsma
Apr 16, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Assia L AngelovaZahari Raykov
Apr 21, 1991·Journal of Theoretical Biology·R E Fisher, H D Mayor
Jul 9, 2008·World Journal of Gastroenterology : WJG·Maike SiebenMarkus Moehler

Related Concepts

African Burkitt's Lymphoma
Cell Transformation, Viral
DNA Replication
DNA, Viral
Gene Amplification
Parvoviridae
Tumor Cells, Cultured
Virus Replication
Superinfection
Leukemia, B-Cell

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