PMID: 9419214Jan 31, 1998Paper

Persistence of peptide-induced CD4+ T cell anergy in vitro

The Journal of Experimental Medicine
K R Ryan, B D Evavold

Abstract

Clonal T cell unresponsiveness, or anergy, has been proposed as a mechanism of peripheral tolerance in vivo, and as a potential means of curbing unwanted T cell responses. In this study, anergy was induced in a T helper cell (Th) clone reactive to hemoglobin (Hb) peptide 64-76 by coculture of the T cells with live antigen-presenting cells (APCs) and 74L, a peptide analog of Hb(64-76) that contains a single amino acid substitution of leucine for glycine at position 74, or with a low concentration of the agonist ligand. The anergic state was characterized by blunted proliferation and interleukin (IL) 2 production upon restimulation with Hb(64-76), and was not the result of impaired TCR/CD3 downmodulation. The addition of exogenous IL-12 transiently restored proliferation of the anergic lines, but removal of IL-12 from culture returned the T cells to their nonproliferative state. Interestingly, persistence of the anergic phenotype was observed despite biweekly restimulation with antigen, APCs, and IL-2. Thus, T cell unresponsiveness induced by a peptide produced a stable, persistent anergic state in a Th0 clone that was not reversible by stimulation with IL-2 or -12.

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Citations

Nov 12, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Joseph J SabatinoBrian D Evavold
Mar 27, 2001·Transplantation Proceedings·L FrascaG Lombardi
May 13, 1998·Immunology Today·R TobesJ Martín
Jan 29, 2000·Immunology and Cell Biology·J D Hayball, R A Lake
Dec 15, 2000·Immunology and Cell Biology·J D Hayball, R A Lake
Nov 6, 2002·The Journal of Experimental Medicine·Markus MunderVijay K Kuchroo
Oct 7, 2006·Current Opinion in Gastroenterology·A M Mowat
Feb 4, 1999·Allergy·M J Thomas, D M Kemeny
Apr 24, 2008·Journal of Leukocyte Biology·Amy E AndersonCatharien M U Hilkens
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·M KaufmanO Leo
Mar 1, 2011·Journal of Theoretical Biology·Koichi Saeki, Yoh Iwasa
Jul 29, 2005·Immunological Reviews·Ana M C Faria, Howard L Weiner
Jul 31, 2013·Journal of Autoimmunity·Lindsay J Edwards, Brian D Evavold
Jun 30, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A K DeC L Miller-Graziano
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H AppelK W Wucherpfennig
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mandy L Ford, Brian D Evavold
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M N AviceM Sarfati
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph J SabatinoBrian D Evavold
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guang-Xian ZhangAbdolmohamad Rostami
May 24, 2018·Annals of Hematology·Elsa M CardosoFernando A Arosa
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carrie D MargotBrian D Evavold
Jun 29, 2021·Frontiers in Immunology·Robin A WelshScheherazade Sadegh-Nasseri

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