PMID: 9534679Apr 16, 1998Paper

Persistence of protective immunity after postexposure prophylaxis of varicella with oral aciclovir in the family setting

Archives of Disease in Childhood
T YoshikawaY Asano

Abstract

The persistence of protective immunity after postexposure prophylaxis against varicella using oral aciclovir was evaluated in the family setting. Sixty one of 78 recipients of oral aciclovir were assessed by questionnaire, and 13 of 61 were evaluated for serum antibody to varicella zoster virus (VZV) using the fluorescent antibody to membrane antigen method. The observation period ranged from 33 to 50 months. None of those (n = 44) who had initially seroconverted to VZV after aciclovir prophylaxis developed breakthrough varicella. All 13 who had serology repeated still had titres > or = 4. Antibody titres in those who had histories of re-exposure to the virus were significantly higher than in those who had not (p < 0.01).

References

Feb 1, 1995·The Pediatric Infectious Disease Journal·Y C HuangC H Chiu
Aug 23, 1962·The New England Journal of Medicine·A H ROSS

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Citations

Nov 16, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martina PrelogLothar Bernd Zimmerhackl
Jun 9, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Fiona CresswellDerek Macallan
Jun 2, 2009·The Lancet Oncology·Mini Kamboj, Kent A Sepkowitz
Aug 18, 2005·European Journal of Haematology·Khalid Ahmed Al-AnaziDavid Alan Price Evans
Apr 2, 2011·Current Opinion in Infectious Diseases·Jonathan P H FisherSophie Hambleton

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