Persistence of protective immunity following vaccination against tick-borne encephalitis--longer than expected?

Vaccine
P Rendi-WagnerHerwig Kollaritsch

Abstract

A descriptive evaluation of protective immunity was performed on subjects with a complete primary tick-borne encephalitis (TBE) immunization (and additional regular boosters) more than 3 years after primary or booster TBE immunization, as measured by neutralization test and two different ELISA systems. The study population (n = 430) was stratified for age (i.e., 18-49 or 50 years of age) and for the number of years since last TBE vaccination. GMTs (NT) of all subgroups (at the time of the present evaluation) were above detection limit: 144 and 44 for the 18-49- and 50-year-old subjects, respectively. One percent of subjects aged 18-49 years, and 6% of subjects aged 50 years were ELISA-negative. A detailed sub analysis revealed that subjects with either low NT and/or negative to borderline ELISA test results are usually older and constitute a higher number of subjects without any TBE booster vaccination compared to the respective test-positive subject group. From the fourth year (exceeding 3 years after last vaccination) titers show a decline rate of 6-7%. This study indicates that after multiple TBE (booster) immunizations protection surpasses the currently advised TBE booster interval of 3 years, thus supporting reconsideratio...Continue Reading

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Citations

Oct 14, 2005·Expert Review of Vaccines·Olaf Zent, Michael Bröker
Jun 20, 2008·Expert Review of Vaccines·Pamela Rendi-Wagner
Feb 10, 2016·Journal of Travel Medicine·Annelies AerssensPatrick Soentjens
Sep 22, 2010·Vaccine·Marta Grgič-VitekIrena Klavs
Oct 26, 2010·Travel Medicine and Infectious Disease·Ursula Wiedermann
May 4, 2010·Vaccine·Eva Maria PöllabauerHartmut J Ehrlich
Nov 6, 2008·Travel Medicine and Infectious Disease·Angelika BanzhoffOlaf Zent
Sep 18, 2007·Vaccine·Franz X HeinzMichael Kundi
Oct 20, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·N GuérinUNKNOWN Groupe de pédiatrie tropicale de la Société française de pédiatrie
Nov 27, 2008·Pediatric Transplantation·Klara M Posfay-Barbe, Claire-Anne Siegrist
Jun 20, 2012·Journal of Medical Virology·Tatjana BaldovinVincenzo Baldo
Aug 30, 2008·Infectious Disease Clinics of North America·Reinhard Kaiser
Mar 10, 2006·International Journal of Medical Microbiology : IJMM·Pamela Rendi-WagnerHerwig Kollaritsch
Mar 15, 2006·International Journal of Medical Microbiology : IJMM·Ines SchöndorfAngelika Banzhoff
Feb 5, 2013·Human Vaccines & Immunotherapeutics·Daniela AmiciziaRoberto Gasparini
Apr 17, 2014·Pathogens and Disease·Luwanika MleraMarshall E Bloom
Apr 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Beran
Jan 25, 2019·The Journal of Veterinary Medical Science·Kentaro Yoshii
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Feb 1, 2017·PLoS Neglected Tropical Diseases·Luwanika MleraMarshall E Bloom
Dec 8, 2005·CNS Drugs·Göran Günther, Mats Haglund
Aug 19, 2020·Vaccines·Mareike KubinskiGuus F Rimmelzwaan

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