Persistence of secondary mitral regurgitation and response to cardiac resynchronization therapy

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
Fernando Cabrera-BuenoEduardo de Teresa

Abstract

Cardiac resynchronization therapy (CRT) improves survival and quality of life in advanced heart failure (HF). Although mitral regurgitation (MR) reduction has been reported, its presence has been associated with non-response to CRT. This study was undertaken to assess the potential role of significant mitral regurgitation (SMR) persistence after CRT on clinical outcome, major arrhythmic events, and echocardiographic response in the mid-long term. Seventy-six patients (28.9% women, 63 +/- 11 years) with dilated cardiomyopathy in advanced HF were included. SMR, defined as regurgitant orifice area > or =0.20 cm(2), was assessed at baseline and its evolution 6 months after CRT. Clinical outcome (cardiovascular death/HF readmission), major arrhythmic events, and echocardiographic response (reverse remodelling) were recorded on follow-up. Thirty-two patients (42.1%) presented baseline SMR, becoming non-significant in 11 of the 32 patients (34.3%) 6 months after CRT. Its persistence was associated with higher rates of clinical events (46.4 vs. 18.7%, P = 0.011), arrhythmic events (35.7 vs. 14.5%, P = 0.034), and less reverse remodelling (28.5 vs. 83.3%, P < 0.001). CRT can reduce moderate or severe baseline MR to non-significant in on...Continue Reading

References

Mar 1, 1995·Journal of the American College of Cardiology·M Enriquez-SaranoJ B Seward
Sep 1, 1993·Journal of the American College of Cardiology·M D TischlerM M LeWinter
Oct 16, 1999·Journal of the American College of Cardiology·M Enriquez-SaranoA J Tajik
Jul 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S F BollingF D Pagani
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
Mar 12, 2003·Journal of the American College of Cardiology·Ole A BreithardtChristoph Stellbrink
Apr 2, 2003·Circulation·Martin G St John SuttonUNKNOWN Multicenter InSync Randomized Clinical Evaluation (MIRACLE) Study Group
Jul 2, 2003·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·William A ZoghbiUNKNOWN American Society of Echocardiography
Mar 12, 2004·Journal of the American College of Cardiology·Blase A Carabello
Nov 30, 2004·The American Journal of Cardiology·Patrizio LancellottiLuc A Piérard
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
May 20, 2005·European Heart Journal·Karl SwedbergUNKNOWN Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology
Jun 14, 2005·The American Journal of Cardiology·Ernesto Díaz-InfanteUNKNOWN SCARS Investigators
Dec 28, 2005·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Maria Cristina PorcianiLuigi Padeletti
Apr 21, 2006·Journal of Cardiac Failure·Thomas P CappolaMartin St John Sutton
Jun 19, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fernando Cabrera-BuenoEduardo de Teresa-Galván
Feb 29, 2008·European Heart Journal·Claudia YpenburgJeroen J Bax
Jul 26, 2008·Journal of the American College of Cardiology·Blase A Carabello
Nov 7, 2008·Echocardiography·Dragos Vinereanu
Feb 14, 2009·Journal of the American College of Cardiology·John G F ClelandNick Freemantle

❮ Previous
Next ❯

Citations

Aug 27, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fernando Cabrera-BuenoFrancisco Javier Alzueta-Rodriguez
Mar 15, 2014·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Jacek KowalczykUNKNOWN Triple-Site Versus Standard Cardiac Resynchronization Trial (TRUST CRT) Investigators
Feb 4, 2016·European Heart Journal Cardiovascular Imaging·Marco SparteraUNKNOWN Echocardiographic Study Group of the Italian Society of Cardiology (SIC)
Jun 19, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Fernando Cabrera-BuenoJavier Alzueta
May 5, 2018·Expert Review of Medical Devices·Judith E LowryKlaus K Witte
Aug 16, 2016·Circulation. Cardiovascular Imaging·Anna Sannino, Paul A Grayburn
Dec 25, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Prabhat KumarJagmeet P Singh
Nov 28, 2013·Current Cardiology Reports·Amelia Young, Ted Feldman
Jul 29, 2016·Current Opinion in Cardiology·Aeshita DwivediMuhamed Saric
Apr 12, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Liliana StefanJosef Kautzner
Apr 14, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Luigi Di BiaseAndrea Natale
Dec 3, 2011·Pacing and Clinical Electrophysiology : PACE·Giuseppe BorianiUNKNOWN InSync/InSync ICD Italian Registry Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.