Persistence of Staphylococcus aureus : Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)

Frontiers in Microbiology
Lorena TuchscherrRichard A Proctor

Abstract

Staphylococcus aureus is able to survive within host cells by switching its phenotype to the small-colony variant (SCV) phenotype. The emergence of SCVs is associated with the development of persistent infections, which may be both chronic and recurrent. This slow-growing subpopulation of S. aureus forms small colonies on solid-medium agar, is induced within host cells, presents a non-homogenous genetic background, has reduced expression of virulence factors and presents a variable phenotype (stable or unstable). While virtually all SCVs isolated from clinical specimens can revert to the parental state with rapid growth, the stable SCVs recovered in clinical specimens have been found to contain specific mutations in metabolic pathways. In contrast, other non-stable SCVs are originated from regulatory mechanisms involving global regulators (e.g., sigB, sarA, and agr) or other non-defined mutations. One major characteristic of SCVs was the observation that SCVs were recovered from five patients with infections that could persist for decades. In these five cases, the SCVs had defects in electron transport. This linked persistent infections with SCVs. The term "persistent infection" is a clinical term wherein bacteria remain in the...Continue Reading

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Citations

Feb 8, 2021·Cellular Microbiology·Ye Mon SoeAbderrahman Hachani
Feb 23, 2021·Frontiers in Immunology·Christopher M Horn, Tammy Kielian
Apr 4, 2021·Toxins·Cassandra PougetJean-Philippe Lavigne
May 1, 2021·Toxins·Bettina Löffler, Lorena Tuchscherr
Jun 3, 2021·Microorganisms·Rajan P Adhikari
Jul 24, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Agnieszka Bogut, Agnieszka Magryś
Aug 18, 2020·Microbial Pathogenesis·Ahmad NasserSamaneh Ostadmohammadi
Sep 24, 2021·Frontiers in Microbiology·Jean-Philippe LavigneAlbert Sotto
Oct 13, 2021·MSystems·Charlotte OriolAstrid Rouillon
Dec 18, 2021·The Journal of Antimicrobial Chemotherapy·Ying JianMin Li
Jan 20, 2022·Journal of Proteome Research·Fouad ChoueiryJiangjiang Zhu

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