Abstract
We studied the effect of birth size on glucose and insulin metabolism among old non-diabetic individuals. We also explored the combined effect of birth size and midlife body mass index (BMI) on type 2 diabetes in old age. Our study comprised 1,682 Icelanders whose birth records included anthropometrical data. The same individuals had participated in the prospective population-based Reykjavik Study, where BMI was assessed at a mean age of 47 years, and in the AGES-Reykjavik Study during 2002 to 2006, where fasting glucose, insulin and HbA1c were measured and homeostasis model assessment for the degree of insulin resistance (HOMA-IR) calculated at a mean age of 75.5 years. Type 2 diabetes was determined as having a history of diabetes, using glucose-modifying medication or fasting glucose of >7.0 mmol/l. Of the participants, 249 had prevalent type 2 diabetes in old age. Lower birth weight and body length were associated with higher fasting glucose, insulin, HOMA-IR and HbA1c among old non-diabetic individuals. Higher birth weight and ponderal index at birth decreased the risk for type 2 diabetes in old age, odds ratio (OR), 0.61 [95 % confidence interval (CI), 0.48-0.79] and 0.96 (95 % CI, 0.92-1.00), respectively. Compared with ...Continue Reading
References
Jul 1, 1992·Diabetologia·C N Hales, D J Barker
Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jul 15, 1995·BMJ : British Medical Journal·D J Barker
Jan 15, 1995·Annals of Internal Medicine·E SigurdssonN Sigfusson
Feb 17, 1996·BMJ : British Medical Journal·H O LithellD A Leon
Apr 1, 1997·Diabetologia·P PoulsenH Beck-Nielsen
Jun 1, 1997·Diabetic Medicine : a Journal of the British Diabetic Association·S VilbergssonN Sigfusson
Feb 12, 1998·Diabetologia·A GarofanoB Bréant
Feb 5, 1998·Lancet·A C RavelliO P Bleker
May 29, 1999·Lancet·A T Hattersley, J E Tooke
Jul 25, 2000·Annals of Internal Medicine·T ForsénD Barker
Sep 26, 2000·European Journal of Clinical Nutrition·H Atladottir, I Thorsdottir
Nov 18, 2000·Hypertension·J ErikssonD Barker
Feb 15, 2001·International Journal of Epidemiology·J E Harding
Mar 23, 2002·Journal of Hypertension·Ingibjorg GunnarsdottirInga Thorsdottir
Jul 30, 2002·The American Journal of Clinical Nutrition·Bryndis E BirgisdottirRafn Benediktsson
Jan 28, 2003·Diabetes Care·Pascal ImbeaultAngelo Tremblay
May 13, 2003·The Journal of Endocrinology·S E OzanneL Mosthaf-Seedorf
Oct 28, 2003·Diabetes Care·Johan G ErikssonDavid J P Barker
Jan 30, 2004·Journal of Internal Medicine·M ErikssonK Svärdsudd
Feb 27, 2004·The New England Journal of Medicine·Santosh K BhargavaKolli Srinath Reddy
Jul 23, 2004·Nature·Patrick BatesonSonia E Sultan
Mar 15, 2005·International Journal of Epidemiology·Eero KajantieJohan G Eriksson
Sep 23, 2006·European Journal of Endocrinology·Jing-Yan TianMin Luo
Oct 4, 2006·Diabetologia·D A LawlorD A Leon
Nov 14, 2006·Lancet·Jaana LindströmUNKNOWN Finnish Diabetes Prevention Study Group
Mar 14, 2007·American Journal of Epidemiology·Tamara B HarrisVilmundur Gudnason
Dec 18, 2007·Diabetes Care·Ervin SzokeJohn E Gerich
Sep 10, 2008·Primary Care Diabetes·Leif LapidusLauren Lissner
Dec 26, 2008·JAMA : the Journal of the American Medical Association·Peter H WhincupDonald E Yarbrough
Mar 25, 2009·Circulation·Sarah Rosner PreisCaroline S Fox
May 5, 2009·European Journal of Epidemiology·Elin OlafsdottirVilmundur Gudnason
May 28, 2009·JAMA : the Journal of the American Medical Association·Juliana C N ChanFrank B Hu
Jun 28, 2011·Lancet·Goodarz DanaeiUNKNOWN Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose)
Citations
Oct 14, 2014·Annals of Medicine·Mikaela B von BonsdorffJohan G Eriksson
May 20, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A InkerAndrew S Levey
Feb 5, 2013·Medical Hypotheses·S DenicM G Nicholls
Nov 22, 2017·BMC Medical Genetics·Srdjan Denic, Mukesh M Agarwal
Nov 30, 2018·Journal of the American Heart Association·Marianne Ravn KnopTao Huang
Mar 8, 2018·PloS One·Kyle EdmundsPaolo Gargiulo
May 5, 2017·Scientific Reports·Ming WuChong Shen
Dec 30, 2017·Experimental and Therapeutic Medicine·Donghua MiLiyong Zhong