Persistence of upper respiratory tract infections in a cohort followed from childhood to adulthood

Family Practice
Maroeska M RoversAnne G M Schilder

Abstract

To assess (1) prevalences of recurrent URTIs (rURTIs) and relapsing/persistent rURTIs and associated medical consumption between 0 and 21 years of age and (2) whether rURTIs experienced in early life predispose to upper airway disease later in life. A cohort of all children born in Nijmegen, The Netherlands, between September 1982 and September 1983, was assessed repeatedly from 2 to 21 years of age with questionnaires regarding infections of the upper respiratory tract (URTIs), use of antibiotics, ENT operations and known risk factors for URTIs. One hundred and sixty-one of the 693 cohort member (23%) suffered from relapsing rURTIs between 0 and 21 years of age, whereas only 7 (1%) suffered from persistent rURTIs throughout this period. Two hundred and six (30%) had used antibiotics more than once; and 220 (32%) had undergone at least one ENT operation. Of the 166 participants with rURTI between 8 and 21 years, 140 (84%) had had rURTI before. rURTIs are highly prevalent throughout early life and associated medical consumption is substantial. The challenge therefore is to develop therapeutic/preventive strategies that will prevent rURTIs in the first years of life.

Citations

Nov 9, 2011·Orphanet Journal of Rare Diseases·Maurizio ScarpaUNKNOWN Hunter Syndrome Europena Expert Council
Aug 5, 2010·American Journal of Medical Genetics. Part a·Tjitske KleefstraConny M A van Ravenswaaij-Arts
Oct 21, 2006·The Cochrane Database of Systematic Reviews·B E Del-Rio-NavarroJ J L Sienra-Monge

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