Persistence of Varicella-Zoster Virus Cell-Mediated Immunity After the Administration of a Second Dose of Live Herpes Zoster Vaccine

The Journal of Infectious Diseases
Adriana WeinbergMyron J Levin

Abstract

Protection against zoster conferred by zoster vaccine live (ZVL; Zostavax) wanes over time. We compared varicella-zoster virus cell-mediated immunity (VZV-CMI) of adults ≥70 years who received a second dose of ZVL ≥10 years after the initial dose with de novo-immunized age-matched controls. Before and during the first year after vaccination, VZV-CMI was significantly higher in reimmunized compared with de novo vaccinees. At 3 years, VZV-CMI differences between groups decreased and only memory responses remained marginally higher in reimmunized participants. In conclusion, the increase in VZV-CMI generated by reimmunization with ZVL is at least equally persistent compared with de novo immunization.

References

Apr 19, 2008·The Journal of Infectious Diseases·M J LevinUNKNOWN Veterans Affairs Cooperative Studies Program Shingles Prevention Study Investigators
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Citations

Jan 25, 2019·Human Vaccines & Immunotherapeutics·Myron J Levin, Adriana Weinberg
Mar 28, 2019·Current Medical Research and Opinion·Helen SenderovichMaheen Mujtaba
Dec 19, 2018·BMC Medicine·Chester B GoodInmaculada Hernandez
Nov 13, 2020·Frontiers in Immunology·Branca PereiraArne N Akbar
Feb 24, 2021·BMJ : British Medical Journal·Anthony L CunninghamMyron J Levin
Jun 1, 2021·Frontiers in Immunology·Miguel Ángel Palacios-PedreroGiulietta Saletti

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