Persistence of vibrissal motor representation following vibrissal pad deafferentation in adult rats

Experimental Brain Research
Gianfranco Franchi

Abstract

The effect of sensory vibrissal pad denervation on M1 organization was studied in adult rats 2 weeks after the infraorbital nerve was severed. Cortical motor output organization was assessed mapping the representation size and thresholds of vibrissa movements evoked by intracortical electrical microstimulation (ICMS). Motor cortex output patterns of control and sham groups of rats were compared with those of rats that had received unilateral or bilateral infraorbital nerve lesions. The mean size of the vibrissa representation in both unilateral and bilateral input-deprived hemispheres was not significantly different from those in control and sham hemispheres. The mean threshold required to evoke vibrissa movements was significantly higher in both groups of deafferented hemispheres than in control and sham groups of hemispheres. In contrast, the mean threshold required to evoke other types of movements from both groups of input-deprived hemispheres were similar to those found in the control and sham groups of hemispheres. These results indicate that input-deprived vibrissal motor representation reflects lower-than-normal excitability, although the size and topographic relationship with neighboring representations are normal.

Citations

Sep 14, 2007·Somatosensory & Motor Research·Kazunori AdachiBarry J Sessle
Nov 10, 2009·Experimental Neurology·Marina MartinezJean-Michel Brezun
Sep 24, 2004·The European Journal of Neuroscience·Gianfranco Franchi, Carlo Veronesi
Feb 4, 2010·The Journal of Comparative Neurology·Limor Avivi-ArberBarry J Sessle
Apr 22, 2006·Experimental Neurology·Carlo VeronesiGianfranco Franchi
Dec 19, 2006·Archives of Oral Biology·B J SessleK Yoshino
Jan 30, 2015·The Journal of Comparative Neurology·Mandeep SoodBarry J Sessle
May 10, 2011·Archives of Oral Biology·Limor Avivi-ArberBarry J Sessle
Aug 28, 2015·Journal of Dental Research·L Avivi-ArberB J Sessle
Mar 9, 2018·Frontiers in Behavioral Neuroscience·Pierantonio ParmianiGianfranco Franchi

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