Persistence rates and medical costs of biological therapies for psoriasis treatment in Japan: a real-world data study using a claims database

BMC Dermatology
Rosarin SruamsiriJörg Mahlich

Abstract

Biological therapies (BTs) including infliximab (IFX), adalimumab (ADL), secukinumab (SCK) and ustekinumab (UST) are approved in Japan for the treatment of psoriasis. Although the persistence rates and medical costs of BTs treatment have been investigated in multiple foreign studies in recent years, few such studies have been conducted in Japan and the differences between patients who adhered to treatment and those who did not have not been reported. This study is aimed at investigating the persistence rates and medical costs of BTs in the treatment of psoriasis in Japan, using the real-world data from a large-scale claims database. Claims data from the JMDC database (August 2009 to December 2016) were used for this analysis. Patient data were extracted using the ICD10 code for psoriasis and claims records of BT injections. Twelve-month and 24-month persistence rates of BTs were estimated by Kaplan-Meier methodology, and 12-month-medical costs before and after BT initiation were compared between persistent and non-persistent patient groups at 12 months. A total of 205 psoriasis patients treated with BTs (BT-naïve patients: 177) were identified. The 12-month/24-month persistence rates for ADL, IFX, SCK, and UST in BT-naïve patie...Continue Reading

References

Jun 8, 2006·Health and Quality of Life Outcomes·Monali J BhosleRajesh Balkrishnan
May 29, 2012·The Journal of Dermatological Treatment·Atsuyuki IgarashiBrad Schenkel
Apr 30, 2013·The Journal of Dermatological Treatment·Vito Di LerniaElena Ficarelli
Oct 15, 2013·The British Journal of Dermatology·L HsuA W Armstrong
Dec 7, 2013·The Journal of Dermatology·Yoshinori UmezawaHidemi Nakagawa
Mar 8, 2016·Journal of the American Academy of Dermatology·Jalpa A DoshiJoel M Gelfand
Apr 18, 2016·The Journal of Investigative Dermatology·Zenas Z N YiuRichard B Warren
Nov 24, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Tobias ArnoldWiebke K Peitsch
May 12, 2017·International Journal of Women's Dermatology·Martina L PorterAlexa B Kimball
Jun 14, 2017·The Journal of Dermatological Treatment·Shinichi ImafukuAnnie Guerin
Feb 23, 2018·Rheumatology and Therapy·Florent GuelfucciRosarin Sruamsiri

❮ Previous
Next ❯

Citations

Apr 16, 2019·The Journal of Dermatology·Yayoi TadaIsao Kawaguchi
Feb 4, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Florence AssanUNKNOWN and Psobioteq
Dec 25, 2021·Dermatology and Therapy·Masayuki TanakaTaichi Nakamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.